ReviewBrain sciences2019
A Focus on the Functions of Area 25.
Review in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
- Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway.Molecular psychiatry · 2026Article
- Differential effects of cognitive training and aerobic exercise on regional gray matter volume and inter-regional covariance in community-dwelling older adults.Scientific reports · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Recent advances in model systems for interrogating diseases of brain aging and associated dementia: Toward human-relevant endophenotypes.Current opinion in neurobiology · 2025Review
- The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Multimodal population study reveals the neurobiological underpinnings of chronotype.Nature human behaviour · 2025Article
- Mapping Genetic Associations With Functional Brain Area Alterations in Schizophrenia and Implications for Cortical Development.Brain and behavior · 2025Article
- Antidepressant effects of ershiwei roudoukou pills and its active ingredient Macelignan: Multiple mechanisms involving oxidative stress, neuroinflammation and synaptic plasticity.Translational psychiatry · 2025Article
- Social Buffering of Posttraumatic Stress Disorder: Longitudinal Effects and Neural Mediators.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Neural representations of noncentral events during narrative encoding predict subsequent story ending originality.Science advances · 2025Article
- Differences in Anatomical Structures and Resting-State Brain Networks Between Elite Wrestlers and Handball Athletes.Brain sciences · 2025Article
- Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices.Frontiers in neuroanatomy · 2025Article
- An infralimbic cortex neuronal ensemble encoded during learning attenuates fear generalization expression.bioRxiv : the preprint server for biology · 2024Article
- Comparing mouse and human cingulate cortex organization using functional connectivity.Brain structure & function · 2024Article
- The Role of the Medial Prefrontal Cortex in Spatial Margin of Safety Calculations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Disentangling transcriptomic heterogeneity within the human subgenual anterior cingulate cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.IEEE transactions on bio-medical engineering · 2024Article
- Alexithymia and estimated 10-year cardiovascular disease risk in healthy adults: a community-based cross-sectional study.Frontiers in psychology · 2024Article
- Subgenual and Hippocampal Pathways in Amygdala Are Set to Balance Affect and Context Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Differential Modulation of Dorsal Raphe Serotonergic Activity in Rat Brain by the Infralimbic and Prelimbic Cortices.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Subcallosal area 25 is one of the least understood regions of the anterior cingulate cortex, but activity in this area is emerging as a crucial correlate of mood and affective disorder symptomatology. The cortical and subcortical connectivity of area 25 suggests it may act as an interface between the bioregulatory and emotional states that are aberrant in disorders such as depression. However, evidence for such a role is limited because of uncertainty over the functional homologue of area 25 in rodents, which hinders cross-species translation. This emphasizes the need for causal manipulations in monkeys in which area 25, and the prefrontal and cingulate regions in which it is embedded, resemble those of humans more than rodents. In this review, we consider physiological and behavioral evidence from non-pathological and pathological studies in humans and from manipulations of area 25 in monkeys and its putative homologue, the infralimbic cortex (IL), in rodents. We highlight the similarities between area 25 function in monkeys and IL function in rodents with respect to the regulation of reward-driven responses, but also the apparent inconsistencies in the regulation of threat responses, not only between the rodent and monkey literatures, but also within the rodent literature. Overall, we provide evidence for a causal role of area 25 in both the enhanced negative affect and decreased positive affect that is characteristic of affective disorders, and the cardiovascular and endocrine perturbations that accompany these mood changes. We end with a brief consideration of how future studies should be tailored to best translate these findings into the clinic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.