Evidence map›Paper›PMID 31163640›Full record

ArticleMarine drugs2019

Gentisyl Alcohol Inhibits Proliferation and Induces Apoptosis via Mitochondrial Dysfunction and Regulation of MAPK and PI3K/AKT Pathways in Epithelial Ovarian Cancer Cells.

Jiyeon Ham, Whasun Lim, Kyeongwon Kim, Young Mok Heo, Seung Mok Ryu, Dongho Lee, Jae-Jin Kim, Gwonhwa Song

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Antitumor and antibacterial activity of metabolites of endophytic Colletotrichum siamense isolated from coffee (Coffea arabica L. cv IAPAR-59).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Article
  6. Review
  7. Review
  8. Article
  9. MAPK signaling pathway-targeted marine compounds in cancer therapy.Journal of cancer research and clinical oncology · 2021
    Review
  10. Insights into the Role of Oxidative Stress in Ovarian Cancer.Oxidative medicine and cellular longevity · 2021
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jiyeon HamDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea. glorijy76@korea.ac.kr.
Whasun LimDepartment of Food and Nutrition, College of Science and Technology, Kookmin University, Seoul 02707, Korea. wlim@kookmin.ac.kr.
Kyeongwon KimDivision of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea. rudndjs@korea.ac.kr.
Young Mok HeoDivision of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea. hym011@korea.ac.kr.
Seung Mok RyuHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju-si, Jeollanam-do 58245, Korea. smryu@kiom.re.kr.
Dongho LeeDepartment of Biosystem and Biotechnology, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea. dongholee@korea.ac.kr.
Jae-Jin KimDivision of Environmental Science & Ecological Engineering, College of Life Sciences & Biotechnology, Korea University, Seoul 02841, Korea. jae-jinkim@korea.ac.kr.ORCID 0000-0001-8990-2139
Gwonhwa SongDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea. ghsong@korea.ac.kr.ORCID 0000-0003-2817-5323
Korea University · KRKookmin University · KR

Funding

National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) 2017R1A2B4002071
6 · The paper itself

Abstract

Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as small molecules or natural products are required. Gentisyl alcohol is one of the secondary metabolites that can be obtained by purification from bacteria or fungi and is known to have antibacterial, antifungal, antiviral, and anti-cancer effects. In the present study, we verified the effect of gentisyl alcohol derived from marine

Indexed as

Antineoplastic AgentsApoptosisAscomycotaBenzyl AlcoholsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMitochondriaPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt2,5-dihydroxybenzyl alcoholAntineoplastic AgentsBenzyl AlcoholsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktcalcium dysregulationgentisyl alcoholmitochondrial dysfunctionovarian cancer

Identifiers

PMID31163640
PMCPMC6627157
OpenAlexW2947820730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.