Evidence map›Paper›PMID 31163445›Full record

ArticlePublic health genomics2018

Understanding Factors Associated with Uptake of BRCA1/2 Genetic Testing among Orthodox Jewish Women in the USA Using a Mixed-Methods Approach.

Meghna S Trivedi, Hilary Colbeth, Haeseung Yi, Alejandro Vanegas, Rebecca Starck, Wendy K Chung, Paul S Appelbaum, Rita Kukafka, Isaac Schechter, Katherine D Crew

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In one paragraph

Article in Public health genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meghna S TrivediDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA, mst2134@cumc.columbia.edu.
Hilary ColbethDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
Haeseung YiDepartment of Health and Behavior Studies, Teachers College, Columbia University, New York, New York, USA.
Alejandro VanegasDepartment of Biomedical Informatics, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Rebecca StarckInstitute for Applied Research and Community Collaboration (ARCC), Spring Valley, New York, USA.
Wendy K ChungDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Paul S AppelbaumDepartment of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Rita KukafkaDepartment of Biomedical Informatics, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Isaac SchechterInstitute for Applied Research and Community Collaboration (ARCC), Spring Valley, New York, USA.
Katherine D CrewDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Institutional Career Development CoreKL2TR001874 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GENKINGER, JEANINE M., SHIMBO, DAICHI · 2016 to 2025
$13.6M
NCATS NIH HHS KL2 TR001874NCATS NIH HHS UL1 TR000040NCI NIH HHS L30 CA220875NCI NIH HHS P30 CA013696
6 · The paper itself

Abstract

BACKGROUND/

aimsAshkenazi Jews have a 1:40 prevalence of BRCA1/2 mutations. Orthodox Jews are an understudied population with unique cultural and religious factors that may influence BRCA1/2 genetic testing uptake.

methodsUsing a mixed-methods approach, we conducted a cross-sectional survey and focus groups among Orthodox Jewish women in New York/New Jersey to explore factors affecting decision-making about BRCA1/2 genetic testing.

resultsAmong 321 evaluable survey participants, the median age was 47 years (range, 25-82); 56% were Modern Orthodox and 44% Yeshivish/Chassidish/other; 84% were married; 7% had a personal history of breast or ovarian cancer. Nearly 20% of the women had undergone BRCA1/2genetic testing. Predictors of genetic testing uptake included being Modern Orthodox (odds ratio [OR] = 2.31), married (OR = 3.49), and having a personal or family history of breast or ovarian cancer (OR = 9.74). Focus group participants (n = 31) confirmed the importance of rabbinic consultation in medical decision-making and revealed that stigma was a prominent factor in decisions about BRCA1/2 testing due to its potential impact on marriageability.

conclusionIn order to increase the uptake of BRCA1/2 genetic testing among the Orthodox Jewish population, it is crucial to understand religious and cultural factors, such as stigma and effect on marriageability, and engage religious leaders in raising awareness within the community.

Indexed as

BRCA1BRCA2Genetic testingOrthodox Jewish women

Identifiers

PMID31163445
PMCPMC6687531

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