Evidence map›Paper›PMID 31163423›Full record

ArticleNeuroepidemiology2019

Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study.

Dean Shibata, Astrid Suchy-Dicey, Cara L Carty, Tara Madhyastha, Tauqeer Ali, Lyle Best, Thomas J Grabowski, W T Longstreth, Dedra Buchwald

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroepidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Risk factors and population attributable fraction for dementia in American Indians: The Strong Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Dean ShibataDepartment of Radiology, University of Washington, Seattle, Washington, USA, shibatad@uw.edu.
Astrid Suchy-DiceyPartnerships for Native Health, Washington State University, Pullman, Washington, USA.
Cara L CartyPartnerships for Native Health, Washington State University, Pullman, Washington, USA.
Tara MadhyasthaDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Tauqeer AliCenter for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Lyle BestStrong Heart Study-Dakota Center, Eagle Butte, South Dakota, USA.
Thomas J GrabowskiIntegrated Brain Imaging Center, University of Washington, Seattle, Washington, USA.
W T LongstrethDepartment of Neurology, University of Washington, Seattle, Washington, USA.
Dedra BuchwaldPartnerships for Native Health, Washington State University, Pullman, Washington, USA.
University of Washington · USNative Health · USMissouri Breaks Industries Research (United States) · USUniversity of Oklahoma Health Sciences Center · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
The Strong Heart Study, Phase VU01HL041654 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LEE, ELISA TAN · 1988 to 2013
$19.2M
CARDIOVASCULAR DISEASE IN THE PIMA INDIANSU01HL041642 · NHLBI · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1988 to 2013
$12.6M
STRONG HEART FAMILY STUDYU01HL065520 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2000 to 2011
$8.9M
CARDIOVASCULAR DISEASE IN SIOUX INDIANSU01HL041652 · NHLBI · U.S. PHS INDIAN HEALTH SERVICE · PI BEST, LYLE G · 1988 to 2013
$7.9M
Cerebrovascular Disease and its Consequences in the Strong Study CohortR01HL093086 · NHLBI · WASHINGTON STATE UNIVERSITY · PI BUCHWALD, DEDRA S · 2009 to 2013
$7.3M
CVD in American Indians Study and Data Management Center and OK Field CenterR01HL109284 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI STONER, JULIE A · 2013 to 2018
$4.6M
CARDIOVASCULAR EVALUATION--STRONG HEART STUDY PHASE IVU01HL065521 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2000 to 2013
$4.3M
CVD in American Indians Biomarker lab and Arizona Field CenterR01HL109319 · NHLBI · MEDSTAR HEALTH RESEARCH INSTITUTE · PI UMANS, JASON G · 2013 to 2017
$3.6M
CVD in American Indians Genetics CenterR01HL109301 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI COLE, SHELLEY A · 2013 to 2018
$3.2M
CVD in American Indians The Dakota Field CenterR01HL109315 · NHLBI · MISSOURI BREAKS RESEARCH, INC. · PI JOLLY, STACEY · 2013 to 2018
$1.9M
CVD in American Indians: Imaging and Cardiovascular CenterR01HL109282 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEVEREUX, RICHARD B · 2013 to 2018
$793k
NHLBI NIH HHS R01 HL093086NHLBI NIH HHS R01 HL109282NHLBI NIH HHS R01 HL109284NHLBI NIH HHS R01 HL109301NHLBI NIH HHS R01 HL109315NHLBI NIH HHS R01 HL109319NHLBI NIH HHS U01 HL041642NHLBI NIH HHS U01 HL041652NHLBI NIH HHS U01 HL041654NHLBI NIH HHS U01 HL065520NHLBI NIH HHS U01 HL065521NIA NIH HHS P50 AG005136
6 · The paper itself

Abstract

backgroundClinical stroke is prevalent in American Indians, but the lifestyle risk factors for vascular brain injury have not been well-studied in this population. The purpose of this study was to correlate brain magnetic resonance imaging (MRI) findings with obesity, alcohol use, and smoking behaviors in elderly American Indians from the Strong Heart Study.

methodsCranial MRI scans (n = 789) were analyzed for dichotomous measures of infarcts, hemorrhages, white matter hyperintensities (WMH), and cerebral atrophy and continuous measures of total brain, WMH, and hippocampal volume. Poisson regression was used to estimate prevalence ratios, and linear regression was used to estimate measures of association for continuous outcomes. Models were adjusted for the risk factors of interest as well as age, sex, study site, income, education, hypertension, diabetes, and low-density lipoprotein cholesterol.

resultsSmoking was associated with increased hippocampal atrophy (p = 0.002) and increased prevalence of sulcal widening (p < 0.001). Relative to nonsmokers, smokers with more than 25 pack-years of smoking had a 27% (95% CI 7-47%) increased prevalence of high-grade sulci, p = 0.005. Body mass index was inversely associated with prevalence of nonlacunar infarcts and sulcal widening (all p = 0.004). Alcohol use was not significantly associated with any of the measured MRI findings.

conclusionsThis study found similar associations between smoking and vascular brain injury among American Indians, as seen in other populations. In particular, these findings support the role of smoking as a key correlate for cerebral atrophy.

Indexed as

Life StyleAgedAged, 80 and overAlcohol DrinkingBrainCardiovascular DiseasesFemaleHumansIndians, North AmericanMagnetic Resonance ImagingMaleObesityRisk FactorsSmokingStrokeUnited StatesAlcoholAmerican IndianBody mass indexBrain magnetic resonance imagingInfarctsSmoking

Identifiers

PMID31163423
PMCPMC6986811
OpenAlexW2948183788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.