Evidence map›Paper›PMID 31163210›Full record

ArticleNeurotoxicology2019

M100907 and BD 1047 attenuate the acute toxic effects of methamphetamine.

Azizi Ray, Clinton E Canal, J Christopher Ehlen, Kenner C Rice, Kevin Sean Murnane

Open access · greenAbstract read
In one paragraph

Article in Neurotoxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Sigma-1 receptor and seizures.Pharmacological research · 2023
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Azizi RayDepartment of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA.
Clinton E CanalDepartment of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA.
J Christopher EhlenDepartment of Neurobiology, Morehouse School of Medicine, Atlanta, GA, USA.
Kenner C RiceDrug Design and Synthesis Section, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA.
Kevin Sean MurnaneDepartment of Pharmaceutical Sciences, Mercer University College of Pharmacy, Mercer University Health Sciences Center, Atlanta, GA, USA. Electronic address: murnane_ks@mercer.edu.
Mercer University Health Sciences Center · USMorehouse School of Medicine · USNational Institute on Drug Abuse · US

Funding

Defining the role of sleep in resilience to social stressSC1GM127260 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI EHLEN, JOHN CHRISTOPHER · 2018 to 2021
$1.4M
Receptor pharmacology and toxicology of second-generation pyrrolidine "bath salt" cathinonesR21DA040907 · NIDA · NORTHEASTERN UNIVERSITY · PI CANAL, CLINTON E, MURNANE, KEVIN SEAN · 2016 to 2017
$493k
NIDA NIH HHS R21 DA040907NIGMS NIH HHS SC1 GM127260
6 · The paper itself

Abstract

There are no Food and Drug Administration approved pharmacotherapies for methamphetamine (METH) overdose, thus identifying novel drug targets to prevent this devastating adverse event is a public-health imperative. Previous research suggests that serotonin and sigma receptors may contribute to the adverse effects of METH. The present study assessed whether pretreatment with the 5-HT

Indexed as

AnimalsBody TemperatureCentral Nervous System StimulantsElectroencephalographyEthylenediaminesFeverFluorobenzenesLethal Dose 50MaleMethamphetamineMicePiperidinesReceptors, sigmaSeizuresSerotonin 5-HT2 Receptor AntagonistsSigma-1 ReceptorCentral Nervous System StimulantsEthylenediaminesFluorobenzenesMethamphetamineN-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiaminPiperidinesReceptors, sigmaSerotonin 5-HT2 Receptor AntagonistsSigma-1 ReceptorvolinanserinBD 1047ConvulsionsHyperthermiaLethalityM100907MethamphetamineOverdoseSeizure

Identifiers

PMID31163210
PMCPMC6750996
OpenAlexW2947512707

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.