ArticleAmerican journal of ophthalmology2019
Use of High-Resolution Optical Coherence Tomography in the Surgical Management of Ocular Surface Squamous Neoplasia: A Pilot Study.
Article in American journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 43 citations in OpenAlex.
- Safety and efficacy of topical interferon alpha 2B and mitomycin C for localized conjunctival intraepithelial neoplasia: long-term report of their pharmacological safety and efficacy.BMC ophthalmology · 2023Trial
- From Morphology to Biomarkers: Optical Coherence Tomography in Corneal Disease.Diseases (Basel, Switzerland) · 2026Review
- Utility of ultrasound biomicroscopy in detecting invasive ocular surface squamous neoplasia.Indian journal of ophthalmology · 2026Article
- High-Resolution Anterior Segment Optical Coherence Tomography Characteristics of Conjunctival Tumors.Journal of clinical practice and research · 2026Article
- Utilizing artificial intelligence for the diagnosis of ocular surface squamous neoplasia with ultrasound biomicroscopy images.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Anterior Segment Optical Coherence Tomography with Angiography for the Cornea and Ocular Surface.Journal of clinical medicine · 2026Review
- Review
- Ultrasound biomicroscopy and anterior segment OCT in ocular surface squamous neoplasia: complementary roles, case series, and targeted literature review.Frontiers in ophthalmology · 2026Article
- Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025Review
- Integrated imaging in rare eyelid lesions: a case report of palpebral dirofilariosis.Journal of ophthalmic inflammation and infection · 2025Article
- High-resolution optical coherence tomography for screening ocular surface tumors: Historical markers and future directions.World journal of clinical cases · 2025Article
- Management and outcomes of ocular surface squamous neoplasia at a tertiary hospital, South Africa.Eye (London, England) · 2025Article
- Detection of Ocular Surface Squamous Neoplasia Using Artificial Intelligence With Anterior Segment Optical Coherence Tomography.American journal of ophthalmology · 2025Article
- Can high-resolution optical coherence tomography provide an optical biopsy for ocular surface lesions?Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025Review
- Update in the Diagnosis and Management of Ocular Surface Squamous Neoplasia (OSSN).Journal of clinical medicine · 2025Review
- Clinical profile and outcomes of ocular surface squamous neoplasia at the Philippine General Hospital: a retrospective study.International journal of ophthalmology · 2025Article
- Characteristics of conjunctival myxomas on anterior segment optical coherence tomography.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2024Article
- Evaluation of the Cornea by Anterior Segment Optical Coherence Tomography in Diseases of the Cornea.Cureus · 2024Article
- Toluidine blue 1% eye drop versus optical coherence tomography for margin delimitation of ocular surface squamous neoplasia.European journal of ophthalmology · 2024Article
- Medical treatment for ocular surface squamous neoplasia.Eye (London, England) · 2023Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo evaluate whether high-resolution optical coherence tomography (HR-OCT) can detect histologic tumor margins of ocular surface squamous neoplasia (OSSN).
methodsEight eyes of 8 patients with OSSN undergoing excision were studied prospectively. Immediately before surgery, the tumor was imaged using commercially available HR-OCT to identify the conjunctival margins of the neoplastic lesion. The tumor borders of the lesion determined by HR-OCT were mapped in relation to an anatomic reference point and transferred intraoperatively. The tumor was excised with 4-mm margins from the visible edge of the lesion with a "no-touch" technique. The specimens were sent for pathologic analysis and the histologic tumor margin was compared to the HR-OCT predicted tumor border.
resultsMean age of the 8 patients was 67 ± 9.9 years. Seven were male, 7 were white, and, ethnically, 3 were Hispanic. All 8 tumors were bulbar and in the exposure zone. Seven tumors were limbal. Corneal extension was present in 5. Mean tumor area was 17.5 ± 11.1 mm
conclusionsHR-OCT has the potential to predict histologic tumor margins in OSSN. Optical identification of tumor margins could potentially decrease the incidence of residual positive margins and minimize healthy tissue removal. Advances in HR-OCT technology and integration into a microscope for "real-time" imaging are needed to further improve this technique. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.
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