Evidence map›Paper›PMID 31163058›Full record

ArticlePloS one2019

Comparison of foveal avascular zone between optical coherence tomography angiography and fluorescein angiography in patients with retinal vein occlusion.

Jens Ulrich Werner, Felix Böhm, Gabriele E Lang, Jens Dreyhaupt, Gerhard K Lang, Christian Enders

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jens Ulrich WernerDepartment of Ophthalmology, Ulm University, Ulm, Germany.ORCID 0000-0002-2545-8339
Felix BöhmUlm University, Ulm, Germany.ORCID 0000-0002-7291-7737
Gabriele E LangDepartment of Ophthalmology, Ulm University, Ulm, Germany.
Jens DreyhauptInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Gerhard K LangDepartment of Ophthalmology, Ulm University, Ulm, Germany.
Christian EndersDepartment of Ophthalmology, Ulm University, Ulm, Germany.
Universität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare area of foveal avascular zone (FAZ) in different retinal vascular layers in optical coherence tomography angiography (OCTA) and fluorescein angiography (FA) in patients with retinal vein occlusion (RVO). DESIGN AND

methodsProspective cross-sectional comparative study in 47 eyes of 47 patients. FA was recorded with the Zeiss FF450plusIR camera and OCTA was obtained with the Zeiss Cirrus 5000 equipped with the AngioPlex module. Area of FAZ was graded by two independent investigators and calculated with Adobe Photoshop. Analysis for the total study population as well as subgroup analysis for branch retinal vein occlusion (BRVO), central retinal vein occlusion (CRVO) and patients with and without macular edema (ME) was performed.

resultsFor all patients, FAZ was 0.449 mm2 in FA, 0.496 mm2 in OCTA superficial capillary layer (SCL) and 3.168 in OCTA deep capillary layer (DCL). In patients without ME FAZ was 0.288 mm2 in FA, 0.342 mm2 in OCTA SCL and 1.384 mm2 in OCTA DCL. FAZ area measurement in patients with ME revealed 0.482 mm2 in FA, 0.527 mm2 in OCTA SCL and 3.554 mm2 in OCTA DCL.

conclusionsEspecially the SCL of OCTA shows a good agreement to FA in measurement of FAZ in all patients with low limits of variation in patients without ME. There were no considerable differences in BRVO and CRVO. OCTA could replace FA in FAZ area measurement in patients with RVO, especially in those without ME, achieving similar measurements whilst being non-invasive.

Indexed as

Fluorescein AngiographyTomography, Optical CoherenceAgedFemaleFovea CentralisHumansMacular EdemaMaleRetinal Vein Occlusion

Identifiers

PMID31163058
PMCPMC6548381
OpenAlexW2948923296

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.