Evidence map›Paper›PMID 31162948›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Mitochondrial dysfunction causes Ca

Surabhi Sudevan, Mai Takiura, Yukihiko Kubota, Nahoko Higashitani, Michael Cooke, Rebecca A Ellwood, Timothy Etheridge, Nathaniel J Szewczyk, Atsushi Higashitani

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  10. Article
  11. ADAM10-a "multitasker" in sepsis: focus on its posttranslational target.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. International journal of molecular sciences · 2021
    Review
  18. Mitochondrial hydrogen sulfide supplementation improves health in theProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Surabhi SudevanGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Mai TakiuraGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Yukihiko KubotaGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Nahoko HigashitaniGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Michael CookeCollege of Life and Environmental Science, University of Exeter, Exeter, United Kingdom.
Rebecca A EllwoodMedical Research Council (MRC) and Arthritis Research United Kingdom (ARUK) Centre of Musculoskeletal Ageing Research and National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Timothy EtheridgeCollege of Life and Environmental Science, University of Exeter, Exeter, United Kingdom.
Nathaniel J SzewczykMedical Research Council (MRC) and Arthritis Research United Kingdom (ARUK) Centre of Musculoskeletal Ageing Research and National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Atsushi HigashitaniGraduate School of Life Sciences, Tohoku University, Sendai, Japan.
Tohoku University · JPNational Institute for Health Research · GBUniversity of Exeter · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Biotechnology and Biological Sciences Research Council BB/N015894/1Biotechnology and Biological Sciences Research Council BB/P025781/1NIH HHS P40 OD010440
6 · The paper itself

Abstract

Mitochondrial dysfunction impairs muscle health and causes subsequent muscle wasting. This study explores the role of mitochondrial dysfunction as an intramuscular signal for the extracellular matrix (ECM)-based proteolysis and, consequentially, muscle cell dystrophy. We found that inhibition of the mitochondrial electron transport chain causes paralysis as well as muscle structural damage in the nematode

Indexed as

AnimalsAntimycin ABlotting, WesternCaenorhabditis elegansCaenorhabditis elegans ProteinsCalciumDisease Models, AnimalExtracellular MatrixFurinMatrix MetalloproteinasesMitochondriaMuscle, SkeletalMuscular Dystrophy, AnimalMuscular Dystrophy, DuchenneAntimycin ACaenorhabditis elegans ProteinsCalciumFurinMatrix MetalloproteinasesAntimycin AcollagenDMDFurinMMP

Identifiers

PMID31162948
PMCPMC6662967
OpenAlexW2948553400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.