ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019
Risk factors for multidrug-resistant organisms among deceased organ donors.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- [Intensive care strategies for organ protection in patients with severe brain damage and imminent or confirmed irreversible brain death].Die Anaesthesiologie · 2025Review
- ISOT position statement on the feasibility of an organ for transplantation from brain-dead deceased donors: a Delphi consensus.The Lancet regional health. Southeast Asia · 2025Review
- Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids.Frontiers in cellular and infection microbiology · 2025Article
- Multidrug-resistant bacterial infections in the liver transplant setting.Updates in surgery · 2024Review
- Impact of the Five-Year Intervention of an Antimicrobial Stewardship Program on the Optimal Selection of Surgical Prophylaxis in a Hospital without Antibiotic Prescription Restrictions in Costa Rica: A Retrospective Study.Antibiotics (Basel, Switzerland) · 2023Article
- The Next Generation: Mentoring and Diversity in the Antibacterial Resistance Leadership Group.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Epidemiology and Prevention of Early Infections by Multi-Drug-Resistant Organisms in Adults Undergoing Liver Transplant: A Narrative Review.Microorganisms · 2023Review
- Evaluation of donor-derived bacterial infections in lung transplant recipients.Turk gogus kalp damar cerrahisi dergisi · 2023Article
- Optimal Perioperative Antimicrobial Management Strategies of Kidney Transplant Recipients Guided by Metagenomic Next-Generation Sequencing of Deceased Donors' Microbiology Samples.Infection and drug resistance · 2023Article
- Prevention, diagnosis, and management of donor derived infections in pediatric kidney transplant recipients.Frontiers in pediatrics · 2023Review
- Daptomycin-ResistantOpen forum infectious diseases · 2022Article
- Impact of donor multidrug-resistant organisms on solid organ transplant recipient outcomes.Transplant infectious disease : an official journal of the Transplantation Society · 2022Article
- Challenges of Antimicrobial Resistance and Stewardship in Solid Organ Transplant Patients.Current infectious disease reports · 2022Review
- Antibiotic Utilization in Deceased Organ Donors.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Multi-Drug Resistant Organisms Infection Impact on Patients Length of Stay in Respiratory Care Ward.Antibiotics (Basel, Switzerland) · 2021Article
- International Survey on Antibiotic Prophylaxis Approaches for Solid Organ Transplant Recipients and Donors Colonized With Multidrug-Resistant Organisms.Transplant infectious disease : an official journal of the Transplantation SocietyArticle
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14 authors at 5 institutions in 1 country.
Funding
Abstract
Donor infection or colonization with a multidrug-resistant organism (MDRO) affects organ utilization and recipient antibiotic management. Approaches to identifying donors at risk of carrying MDROs are unknown. We sought to determine the risk factors for MDROs among transplant donors. A multicenter retrospective cohort study was conducted at four transplant centers between 2015 and 2016. All deceased donors who donated at least one organ were included. Cultures obtained during the donor's terminal hospitalization and organ procurement were evaluated. The primary outcome was isolation of an MDRO on culture. Multivariable Cox regression was used to determine risk factors associated with time to donor MDRO. Of 440 total donors, 64 (15%) donors grew an MDRO on culture. Predictors of an MDRO on donor culture included hepatitis C viremia (hazard ratio [HR] 4.09, 95% confidence interval [CI] 1.71-9.78, P = .002), need for dialysis (HR 4.59, 95% CI 1.09-19.21, P = .037), prior hematopoietic cell transplant (HR 7.57, 95% CI 1.03-55.75, P = .047), and exposure to antibiotics with a narrow gram-negative spectrum (HR 1.13, 95% CI 1.00-1.27, P = .045). This is the first study to determine risk factors for MDROs among deceased donors and will be important for risk stratifying potential donors and informing transplant recipient prophylaxis.
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