Evidence map›Paper›PMID 31162490›Full record

ArticleJournal of extracellular vesicles2018

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017.

Aled Clayton, Dominik Buschmann, J Brian Byrd, David R F Carter, Lesley Cheng, Carolyn Compton, George Daaboul, Andrew Devitt, Juan Manuel Falcon-Perez, Chris Gardiner and 27 more

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  18. Article
  19. Extracellular vesicle interplay in cardiovascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021
    Review
  20. Reliable measurements of extracellular vesicles by clinical flow cytometry.American journal of reproductive immunology (New York, N.Y. : 1989) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 15 countries.

Aled ClaytonTissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.ORCID 0000-0002-3087-9226
Dominik BuschmannDivision of Animal Physiology and Immunology, Technical University of Munich and Institute of Human Genetics, University Hospital, LMU Munich, Munich, Germany.ORCID 0000-0003-0460-6459
J Brian ByrdDepartment of Internal Medicine, University of Michigan, 5570C MSRB II, Ann Arbor, USA.ORCID 0000-0002-0509-3520
David R F CarterDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Lesley ChengDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Carolyn ComptonSkySong Center for Innovation, Arizona State University, Scottsdale, AZ, USA.
George DaaboulnanoView Diagnostics, Boston, MA, USA.
Andrew DevittSchool of Life & Health Sciences, Aston University, Birmingham, UK.
Juan Manuel Falcon-PerezExosomes Laboratory & Metabolomics Platform, CIC bioGUNE, CIBEREHD, IKERBASQUE Research Foundation, Derio, Spain.
Chris GardinerResearch Department of Haematology, Haemostasis Research, University College London, London, UK.
Dakota GustafsonDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.ORCID 0000-0001-8374-6331
Paul HarrisonInstitute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0003-4610-8909
Clemens HelmbrechtParticle Metrix GmbH, Meerbusch, Germany.
An HendrixLaboratory of Experimental Cancer Research, Department of Radiation Oncology and experimental Cancer Research, Ghent University, Ghent, Belgium; and Cancer Research Institute Ghent, Ghent, Belgium.
Andrew HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.ORCID 0000-0001-5581-2354
Andrew HoffmanRegenerative Medicine Laboratory, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Jennifer C JonesDepartment of Vaccine Branch, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-9488-7719
Raghu KalluriDepartment of Cancer Biology, Metastasis Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
Ji Yoon KangKorea Institute of Science and Technology, Center for Bio-microsystems, Seoul, S. Korea.
Benedikt KirchnerDivision of Animal Physiology and Immunology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.ORCID 0000-0003-3878-0148
Cecilia LässerInstitute of Medicine at Sahlgrenska Academy Krefting Research Centre University of Gothenburg, Gothenburg, Sweden.
Charlotte LawsonDepartment of Comparative Biomedical Sciences, Royal Veterinary College Royal College Street, London, UK.
Metka LenassiInstitute of Biochemistry, University of Ljubljana, Ljubljana, Slovenia.
Carina LevinAfula and The Bruce Rappaport Faculty of Medicine, Emek Medical Center, Technion, Haifa, Israel.
Alicia LlorenteDepartment of Molecular Cell Biology, Oslo University Hospital, Oslo, Norway.
Elena S Martens-UzunovaDepartment of Urology, Erasmus MC, Rotterdam, CA, The Netherlands.
Andreas MöllerTumour Microenvironment Laboratory, Tumour Microenvironment Laboratory, QIMR Berghofer Medical Research Institute, Herston, Australia.
Luca MusanteDepartment of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-6225-8598
Takahiro OchiyaDivision of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan.
Ryan C PinkDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.
Hidetoshi TaharaDepartment of Cellular and Molecular Biology, Institute and Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima City, Japan.
Marca H M WaubenFaculty of Veterinary Medicine, Dept. Biochemistry & Cell Biology, Utrecht University, Utrecht, The Netherlands.
Jason P WebberTissue Microenvironment Group, School of Medicine, Cardiff University, Cardiff, UK.
Joshua A WelshDepartment of Vaccine Branch, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0002-1097-9756
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins Institute for NanoBio Technology, Johns Hopkins University, Baltimore, USA.ORCID 0000-0003-1664-4233
Hang YinSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Rienk NieuwlandDepartment Laboratory Experimental Clinical Chemistry, Academic Medical Center, University of Amsterdam, DE, Amsterdam, The Netherlands.
Cardiff University · GBLa Trobe University · AUNational Cancer Institute · USOxford Brookes University · GBTechnical University of Munich · DEAmsterdam UMC Location University of Amsterdam · NLAston University · GBCenter for Innovation · USCIC bioGUNE · ESEmek Medical Center · ILErasmus MC · NLGhent University · BEHiroshima University · JPJohns Hopkins University · USKorea Institute of Science and Technology · KRMedtronic (Germany) · DEOslo University Hospital · NOQIMR Berghofer Medical Research Institute · AURoyal Veterinary College · GBThe University of Texas MD Anderson Cancer Center · US

Funding

Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
A Novel Biomarker of Mineralocorticoid Receptor ActivationK23HL128909 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BYRD, JAMES BRIAN · 2016 to 2020
$972k
Biotechnology and Biological Sciences Research Council BB/E002080/1NHLBI NIH HHS K23 HL128909
6 · The paper itself

Abstract

This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

Indexed as

Biomarkerscancerexosomesextracellular vesiclesplasmaserumurine

Identifiers

PMID31162490
PMCPMC5965025
OpenAlexW2804149102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.