ReviewJournal of glaucoma2019
Gravitational Influence on Intraocular Pressure: Implications for Spaceflight and Disease.
Review in Journal of glaucoma, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 60 citations in OpenAlex.
- Optic Nerve Vasculature and Countermeasure Assessment in a Bedrest Analogue of Spaceflight-Associated Neuro-Ocular Syndrome.American journal of ophthalmology · 2025Trial
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Anterior segment biomechanics and intraocular pressure in microgravity: implications for future spaceflight studies.NPJ microgravity · 2026Review
- Artificial Intelligence Deep Learning Models to Predict Spaceflight Associated Neuro-Ocular Syndrome.American journal of ophthalmology · 2025Article
- Analysis of Spaceflight-Associated Biometric and Refractive Changes in Astronauts.American journal of ophthalmology · 2025Article
- Prediction of Cerebrospinal Fluid (CSF) Pressure with Generative Adversarial Network Synthetic Plasma-CSF Biomarker Pairing.Neuroinformatics · 2025Article
- Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures.Progress in retinal and eye research · 2025Review
- Ocular Biomechanical Responses to Long-Duration Spaceflight.IEEE open journal of engineering in medicine and biology · 2025Article
- Evolutionary medicine and bioastronautics: an innovative approach in addressing adverse mental health effects to astronauts during long term space missions.Frontiers in physiology · 2025Article
- Artificial Gravity Attenuates the Transcriptomic Response to Spaceflight in the Optic Nerve and Retina.International journal of molecular sciences · 2024Article
- Ocular perfusion pressure is not reduced in response to lower body negative pressure.NPJ microgravity · 2024Article
- Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework.NPJ microgravity · 2024Article
- Navigating the Unknown: A Comprehensive Review of Spaceflight-Associated Neuro-Ocular Syndrome.Cureus · 2024Review
- Light flashes and other sensory illusions perceived in space travel and on ground, including proton and heavy ion therapies.Zeitschrift fur medizinische Physik · 2024Review
- Neuro-ophthalmological changes in healthy females exposed to a 5-day dry immersion: a pilot study.NPJ microgravity · 2024Article
- Spaceflight associated neuro-ocular syndrome: connections with terrestrial eye and brain disorders.Frontiers in ophthalmology · 2024Article
- Posture-Induced Changes in Intraocular, Orbital, Cranial, Jugular Vein, and Arterial Pressures in a Porcine Model.Investigative ophthalmology & visual science · 2023Article
- Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge?Life (Basel, Switzerland) · 2023Review
- Impact of Microgravity and Other Spaceflight Factors on Retina of Vertebrates and Humans In Vivo and In Vitro.Life (Basel, Switzerland) · 2023Review
- Space Environment Impacts Homeostasis: Exposure to Spaceflight Alters Mammary Gland Transportome Genes.Biomolecules · 2023Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Spaceflight-associated neuro-ocular syndrome (SANS) describes a series of morphologic and functional ocular changes in astronauts first reported by Mader and colleagues in 2011. SANS is currently clinically defined by the development of optic disc edema during prolonged exposure to the weightless (microgravity) environment, which currently occurs on International Space Station (ISS). However, as improvements in our understanding of the ocular changes emerge, the definition of SANS is expected to evolve. Other ocular SANS signs that arise during and after ISS missions include hyperopic shifts, globe flattening, choroidal/retinal folds, and cotton wool spots. Over the last 10 years, ~1 in 3 astronauts flying long-duration ISS missions have presented with ≥1 of these ocular findings. Commensurate with research that combines disparate specialties (vision biology and spaceflight medicine), lessons from SANS investigations may also yield insight into ground-based ocular disorders, such as glaucomatous optic neuropathy that may have the potential to lessen the burden of this irreversible cause of vision loss on Earth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.