Evidence map›Paper›PMID 31161966›Full record

ArticleRadiation research2019

Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure.

Kristofer T Michalson, Andrew N Macintyre, Gregory D Sempowski, J Daniel Bourland, Timothy D Howard, Gregory A Hawkins, Gregory O Dugan, J Mark Cline, Thomas C Register

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  5. Review
  6. Long-Term Immunological Consequences of Radiation Exposure in a Diverse Cohort of Rhesus Macaques.International journal of radiation oncology, biology, physics · 2023
    Article
  7. The NIAID/RNCP Biodosimetry Program: An Overview.Cytogenetic and genome research · 2023
    Review
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Kristofer T MichalsonDepartment of a Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Andrew N Macintyred Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.
Gregory D Sempowskid Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.
J Daniel Bourlandb Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Timothy D Howardc Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Gregory A Hawkinsc Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Gregory O DuganDepartment of a Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
J Mark ClineDepartment of a Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Thomas C RegisterDepartment of a Pathology/Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
British Institute of International and Comparative Law · GBDuke University · USWake Forest University · USLaboratoire d'ethnologie et de sociologie comparative · FRRadiation Oncology Associates · US

Funding

Sample Engineering CoreU19AI067773 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FORNACE, ALBERT J · 2005 to 2024
$105.4M
Somatostatin analogues as countermeasures against intestinal radiation toxicityU19AI067798 · NIAID · DUKE UNIVERSITY · PI CHAO, NELSON J. · 2005 to 2024
$82.1M
Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Regional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3M
Laboratory Animal & Comparative Medicine TrainingT32OD010957 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2012 to 2026
$4.3M
Social Stress, Diet. and Primate Monocyte Programming in Cardiovascular RiskR01HL122393 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI REGISTER, THOMAS COSTIN, SHIVELY, CAROL A. · 2015 to 2018
$2.0M
Perkin Elmer Sciclone G3 NGSx Workstation for High Throughput Sequencing Library PreparationS10OD023409 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAWKINS, GREGORY A · 2017 to 2017
$234k
NCI NIH HHS P30 CA012197NHLBI NIH HHS R01 HL122393NIAID NIH HHS U19 AI067773NIAID NIH HHS U19 AI067798NIAID NIH HHS UC6 AI058607NIH HHS S10 OD023409NIH HHS T32 OD010957
6 · The paper itself

Abstract

Radiation-induced fibrosis (RIF) is a common delayed effect of acute ionizing radiation exposure (DEARE) affecting diverse tissues including the heart, lungs, liver and skin, leading to reduced tissue function and increased morbidity. Monocytes, which may be classified into classical (CD14

Indexed as

AnimalsCell PolarityGene Expression RegulationMacaca mulattaMaleMonocytesTime FactorsTranscription, GeneticWhole-Body Irradiation

Identifiers

PMID31161966
PMCPMC6698159
OpenAlexW2948446123

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.