Evidence map›Paper›PMID 31161939›Full record

ReviewJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2019

What Have We Learned from Studies of IFN-λ Variants and Hepatitis C Virus Infection?

Thomas R O'Brien, Sarah S Jackson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Foods (Basel, Switzerland) · 2026
    Article
  2. Frequencies of anInternational journal of molecular sciences · 2024
    Article
  3. Review
  4. HepaticInternational journal of molecular sciences · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Thomas R O'BrienInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Sarah S JacksonInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Division of Cancer Epidemiology and GeneticsNational Cancer Institute · US

Funding

Epidemiology of Oncogenic VirusesZIACP005782 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI O'BRIEN, THOMAS R · 2009 to 2025
$6.7M
6 · The paper itself

Abstract

Chronic infection with the hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma. In 2009, genome-wide association studies (GWAS) strongly linked genetic variants in the interferon lambda (IFN-λ) chromosomal region to HCV clearance. In 2013, discovery of the

Indexed as

AllelesGenetic VariationHepacivirusHepatitis C, ChronicInterleukinsLiver CirrhosisGenome-Wide Association StudyHumansInterferon LambdaIFNL4 protein, humanInterferon LambdaInterleukinsepidemiologyfibrosisgeneticshepatocellular carcinomaIFNL4innate immunitytreatment responseviral clearance

Identifiers

PMID31161939
PMCPMC6767860
OpenAlexW3007293329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.