Evidence map›Paper›PMID 31161888›Full record

ReviewJournal of binocular vision and ocular motility

Fellow Eye Deficits in Amblyopia.

Eileen E Birch, Krista R Kelly, Deborah E Giaschi

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of binocular vision and ocular motility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226141 (Valproate for the Treatment of Residual Amblyopia), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07226141 phase1 / phase2recruitingnot on this map

Valproate for the Treatment of Residual Amblyopia

TypeinterventionalSponsorBoston Children's HospitalRan2026 to 2027Enrolled28ConditionsAmblyopia, Amblyopia Unilateral, Amblyopia, Anisometropic, Amblyopia StrabismicArmsValproate, Placebo, Patch
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Binocular Vision Anomalies: An Update on Prevalence, Impact, Technological and Treatment Developments and Current Challenges.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Temporal Contour Integration Deficits in Children With Amblyopia.Investigative ophthalmology & visual science · 2025
    Article
  14. Article
  15. Article
  16. Rehabilitation of amblyopia using a digital platform for visual training combined with patching in children: a prospective study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  17. Article
  18. Motion-Defined Form Perception in Deprivation Amblyopia.Investigative ophthalmology & visual science · 2024
    Article
  19. Article
  20. Amblyopia and the whole child.Progress in retinal and eye research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eileen E Bircha Crystal Charity Ball Pediatric Vision Laboratory, Retina Foundation of the Southwest , Dallas , Texas.ORCID https://orcid.org/0000-0001-8279-3291
Krista R Kellya Crystal Charity Ball Pediatric Vision Laboratory, Retina Foundation of the Southwest , Dallas , Texas.ORCID https://orcid.org/0000-0003-2531-7082
Deborah E Giaschic Department of Ophthalmology and Visual Sciences, University of British Columbia , Vancouver , British Columbia , Canada.ORCID https://orcid.org/0000-0001-6526-0047

Funding

Binocular Vision, Amblyopia, and Refractive Development in EsotropiaR01EY022313 · NEI · RETINA FOUNDATION OF THE SOUTHWEST · PI Eileen Elizabeth Birch · 2012 to 2026
$7.0M
NEI NIH HHS R01 EY022313
6 · The paper itself

Abstract

Amblyopia is a neurodevelopmental disorder of the visual system, as a result of discordant visual experience during infancy or early childhood. Because amblyopia is typically defined as monocularly reduced visual acuity accompanied by one or more known amblyogenic factors, it is often assumed that the fellow eye is normal and sufficient for tasks like reading and eye-hand coordination. Recent scientific evidence of ocular motor, visual, and visuomotor deficits that are present with fellow eye monocular viewing and with binocular viewing calls this assumption into question. This clinical update reviews the research that has revealed fellow ocular motor and visual deficits and the effect that these deficits have on an amblyopic child's visuomotor and visuocognitive skills. We need to understand how to prevent and rehabilitate the effects of amblyopia not only on the nonpreferred eye but also on the fellow eye.

Indexed as

Diagnostic Techniques, OphthalmologicalAmblyopiaChildHumansOcular Motility DisordersPerceptual DisordersPhysical ExaminationPsychomotor PerformanceVision, BinocularVisual AcuityAmblyopiafellow eyemotion perceptionmotor skillsocular motor

Identifiers

PMID31161888
PMCPMC6673659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.