Evidence map›Paper›PMID 31161857›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.

Yufei Chen, Patricia Ernst

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Anti-leukemic principle(s) fromCytotechnology · 2022
    Article
  6. The MLL/SET family and haematopoiesis.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yufei Chena Department of Pediatrics , Section of Hematology/Oncology/Bone Marrow Transplant, University of Colorado/Anschutz Medical Campus , Aurora , CO , USA.
Patricia Ernsta Department of Pediatrics , Section of Hematology/Oncology/Bone Marrow Transplant, University of Colorado/Anschutz Medical Campus , Aurora , CO , USA.ORCID 0000-0001-7638-2939
University of Colorado Anschutz Medical Campus · US

Funding

MLL Family Histone Methyltransferases in Myeloid LeukemiaR01CA224436 · NCI · UNIVERSITY OF COLORADO DENVER · PI ERNST, PATRICIA · 2018 to 2022
$2.1M
Connecting Epigenetic Regulator MLL1 to ERK and Survival Signaling in B cellsR21AI129426 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ERNST, PATRICIA · 2017 to 2018
$418k
NCI NIH HHS R01 CA224436NIAID NIH HHS R21 AI129426
6 · The paper itself

Abstract

The deregulation of hematopoietic stem cell (HSC) transcriptional networks is a common theme in acute myelogenous leukemia (AML). Chromosomal translocations that alter the

Indexed as

AnimalsAntineoplastic AgentsCarcinogenesisFemaleGene Expression Regulation, LeukemicHEK293 CellsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHistone-Lysine N-MethyltransferaseHumansLeukemia, Myeloid, AcuteMDS1 and EVI1 Complex Locus ProteinMiceMice, Inbred C57BLMice, TransgenicMyeloid-Lymphoid Leukemia ProteinafimoxifeneAntineoplastic AgentsHistone-Lysine N-MethyltransferaseKMT2A protein, humanMDS1 and EVI1 Complex Locus ProteinMecom protein, mouseMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionTamoxifenAMLH3K4histone methyltransferaseKMT2AleukemiaMLLMLL1

Identifiers

PMID31161857
PMCPMC6619971
OpenAlexW2948369835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.