Evidence map›Paper›PMID 31161771›Full record

SynthesisAmerican journal of respiratory and critical care medicine2019

Understanding and Enhancing Sepsis Survivorship. Priorities for Research and Practice.

Hallie C Prescott, Theodore J Iwashyna, Bronagh Blackwood, Thierry Calandra, Linda L Chlan, Karen Choong, Bronwen Connolly, Paul Dark, Luigi Ferrucci, Simon Finfer and 15 more

Abstract readSystematic Review
In one paragraph

Synthesis in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Guideline
  3. Pooled it
  4. Pooled it
  5. Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review.American journal of respiratory and critical care medicine · 2020
    Pooled it
  6. Trial
  7. Trial
  8. Article
  9. Observational
  10. Measuring health-related quality of life in sepsis survivors and caregivers: a mapping review and a preliminary conceptual framework.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Current standard of care for septic shock.Intensive care medicine · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hallie C PrescottDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-8442-6724
Theodore J IwashynaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Michigan.
Bronagh BlackwoodWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.ORCID 0000-0002-4583-5381
Thierry CalandraInfectious Diseases Service, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Linda L ChlanNursing Research Division, Department of Nursing, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, Minnesota.
Karen ChoongDepartment of Pediatrics.
Bronwen ConnollyLane Fox Respiratory Unit, St. Thomas' Hospital, Guy's and St. Thomas' National Health Service Foundation Trust, London, United Kingdom.
Paul DarkNational Specialty Lead for Critical Care, National Institute for Health Research, and.
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Simon FinferThe George Institute for Global Health, University of New South Wales, Sydney, Australia.ORCID 0000-0002-2785-5864
Timothy D GirardClinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0002-9833-4871
Carol HodgsonAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.
Ramona O HopkinsPsychology Department and Neuroscience Center, Brigham Young University, Provo, Utah.
Catherine L HoughDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.
James C JacksonDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee.
Flavia R MachadoAnesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil.
John C MarshallDepartment of Surgery.
Cheryl MisakDepartment of Philosophy, University of Toronto, Toronto, Ontario, Canada.
Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Pinaki PanigrahiDepartment of Pediatrics, Georgetown University Medical Center, Washington, DC.
Konrad ReinhartDepartment of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
Sachin YendeClinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, Massachusetts.
Kathryn M RowanIntensive Care National Audit and Research Centre, London, United Kingdom.
Derek C AngusClinical Research, Investigation, and Systems Modeling of Acute Illness Center, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Funding

Late cardiovascular consequences of septic shockR01GM097471 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YENDE, SACHIN · 2012 to 2016
$2.8M
Mitochondrial Determinants of Cognitive Outcomes in ARDS and Sepsis - SupplementR01HL135144 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GIRARD, TIMOTHY D · 2017 to 2021
$2.2M
General pathways and personalized risk of morbidity after sepsisK08GM115859 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PRESCOTT, HALLIE CHRISTINE · 2015 to 2018
$776k
Department of Health PDF-2015-08-015NHLBI NIH HHS R01 HL135144NIGMS NIH HHS K08 GM115859NIGMS NIH HHS R01 GM097471
6 · The paper itself

Abstract

An estimated 14.1 million patients survive sepsis each year. Many survivors experience poor long-term outcomes, including new or worsened neuropsychological impairment; physical disability; and vulnerability to further health deterioration, including recurrent infection, cardiovascular events, and acute renal failure. However, clinical trials and guidelines have focused on shorter-term survival, so there are few data on promoting longer-term recovery. To address this unmet need, the International Sepsis Forum convened a colloquium in February 2018 titled "Understanding and Enhancing Sepsis Survivorship." The goals were to identify gaps and limitations of current research and shorter- and longer-term priorities for understanding and enhancing sepsis survivorship. Twenty-six experts from eight countries participated. The top short-term priorities identified by nominal group technique culminating in formal voting were to better leverage existing databases for research, develop and disseminate educational resources on postsepsis morbidity, and partner with sepsis survivors to define and achieve research priorities. The top longer-term priorities were to study mechanisms of long-term morbidity through large cohort studies with deep phenotyping, build a harmonized global sepsis registry to facilitate enrollment in cohorts and trials, and complete detailed longitudinal follow-up to characterize the diversity of recovery experiences. This perspective reviews colloquium discussions, the identified priorities, and current initiatives to address them.

Indexed as

Practice Guidelines as TopicSurvivorshipAdultAgedAged, 80 and overBiomedical ResearchCohort StudiesCritical CareFemaleHumansMaleMiddle AgedPersons with DisabilitiesResearch DesignSepsiscritical illnessrehabilitationsurvivorship

Identifiers

PMID31161771
PMCPMC6794113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.