Evidence map›Paper›PMID 31161755›Full record

ReviewJournal of cardiovascular imaging2019

Contrast Enhanced Ultrasound Perfusion Imaging in Skeletal Muscle.

TheAnh Nguyen, Brian P Davidson

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05608824 (Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05608824 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using Shear Wave Elastography and Micro-vascular Flow Imaging

TypeinterventionalSponsorOregon Health and Science UniversityRan2023 to 2025Enrolled9ConditionsLower Extremity Musculoskeletal InjuryArmsShear wave elastography and microvascular flow imaging.
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Noninvasive Diagnosis of Chronic Exertional Compartment Syndrome With Shear Wave Elastography and Subharmonic-Aided Pressure Estimation.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Ultrasonic technologies in imaging and drug delivery.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Experimental Validation of Perfusion Imaging With HOSVD Clutter Filters.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

TheAnh NguyenKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-6616-787X
Brian P DavidsonKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.ORCID https://orcid.org/0000-0002-2965-1873

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to accurately evaluate skeletal muscle microvascular blood flow has broad clinical applications for understanding the regulation of skeletal muscle perfusion in health and disease states. Contrast-enhanced ultrasound (CEU) perfusion imaging, a technique originally developed to evaluate myocardial perfusion, is one of many techniques that have been applied to evaluate skeletal muscle perfusion. Among the advantages of CEU perfusion imaging of skeletal muscle is that it is rapid, safe and performed with equipment already present in most vascular medicine laboratories. The aim of this review is to discuss the use of CEU perfusion imaging in skeletal muscle. This article provides details of the protocols for CEU imaging in skeletal muscle, including two predominant methods for bolus and continuous infusion destruction-replenishment techniques. The importance of stress perfusion imaging will be highlighted, including a discussion of the methods used to produce hyperemic skeletal muscle blood flow. A broad overview of the disease states that have been studied in humans using CEU perfusion imaging of skeletal muscle will be presented including: (1) peripheral arterial disease; (2) sickle cell disease; (3) diabetes; and (4) heart failure. Finally, future applications of CEU imaging in skeletal muscle including therapeutic CEU imaging will be discussed along with technological developments needed to advance the field.

Indexed as

Contrast ultrasoundMicrobubblesSkeletal muscle perfusion

Identifiers

PMID31161755
PMCPMC6669180

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.