Evidence map›Paper›PMID 31161731›Full record

ArticleFEBS open bio2019

Trypanosoma brucei centrin5 is enriched in the flagellum and interacts with other centrins in a calcium-dependent manner.

Fangzhen Shan, Xiao Yang, Yating Diwu, Haoyu Ma, Xiaoming Tu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fangzhen ShanHefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, Hefei, China.
Xiao YangHefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, Hefei, China.
Yating DiwuHefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, Hefei, China.
Haoyu MaHefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, Hefei, China.
Xiaoming TuHefei National Laboratory for Physical Science at Microscale and School of Life Science, University of Science and Technology of China, Hefei, China.
Hefei National Center for Physical Sciences at Nanoscale · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Centrin is an evolutionarily conserved EF-hand-containing protein, which is present in eukaryotic organisms as diverse as algae, yeast, and humans. Centrins are associated with the microtubule-organizing center and with centrosome-related structures, such as basal bodies in flagellar and ciliated cells, and the spindle pole body in yeast. Five centrin genes have been identified in Trypanosoma brucei (T. brucei), a protozoan parasite that causes sleeping sickness in humans and nagana in cattle in sub-Saharan Africa. In the present study, we identified that centrin5 of T. brucei (TbCentrin5) is localized throughout the cytosol and nucleus and enriched in the flagellum. We further identified that TbCentrin5 binds Ca

Indexed as

Amino Acid SequenceAnimalsCalciumCalcium-Binding ProteinsCattleContractile ProteinsCytosolEF Hand MotifsFlagellaHumansPhylogenyProtein BindingProtein Interaction Domains and MotifsTrimethoprim, Sulfamethoxazole Drug CombinationTrypanosoma brucei bruceiCalciumCalcium-Binding ProteinsContractile ProteinsTrimethoprim, Sulfamethoxazole Drug CombinationCa2+ ions bindingprotein interactionsTbCentrin5Trypanosoma brucei

Identifiers

PMID31161731
PMCPMC6668372
OpenAlexW2949057224

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.