Evidence map›Paper›PMID 31161539›Full record

ArticleEJNMMI research2019

Elimination of tumor hypoxia by eribulin demonstrated by

Songji Zhao, Wenwen Yu, Naoyuki Ukon, Chengbo Tan, Ken-Ichi Nishijima, Yoichi Shimizu, Kei Higashikawa, Tohru Shiga, Hiroko Yamashita, Nagara Tamaki and 1 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Eribulin improves tumor oxygenation demonstrated byEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  6. Article
  7. Hypoxia and the phenomenon of immune exclusion.Journal of translational medicine · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Songji ZhaoDepartment of Tracer Kinetics and Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. zhao-s@fmu.ac.jp.
Wenwen YuDepartment of Tracer Kinetics and Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Naoyuki UkonAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan.
Chengbo TanAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan.
Ken-Ichi NishijimaCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Yoichi ShimizuFaculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Kei HigashikawaCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Tohru ShigaDepartment of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Hiroko YamashitaDepartment of Breast Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Nagara TamakiDepartment of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yuji KugeCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Hokkaido University · JPFukushima Medical University · JPHokkaido University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEribulin, an inhibitor of microtubule dynamics, shows antitumor potency against a variety of solid cancers through its antivascular activity and remodeling of tumor vasculature. MATERIAL AND

methodsMice bearing a human cancer cell xenograft were intraperitoneally administered a single dose of eribulin (0.3 or 1.0 mg/kg) or saline. Three days after the treatment, mice were injected with

resultsThe

conclusionsUsing

Indexed as

18F-FMISO PET imagingEribulinHuman tumor xenograft modelRemodeling of tumor vasculatureTumor hypoxia

Identifiers

PMID31161539
PMCPMC6546772
OpenAlexW2948790758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.