Evidence map›Paper›PMID 31161417›Full record

ArticleInternational archives of occupational and environmental health2019

Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China.

Kyoung-Mu Lee, Bryan A Bassig, Luoping Zhang, Roel C Vermeulen, Wei Hu, Jason Y Y Wong, Chuangyi Qiu, Cuiju Wen, Yongshun Huang, Mark P Purdue and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International archives of occupational and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Kyoung-Mu LeeOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA. kmlee92@knou.ac.kr.ORCID 0000-0003-4100-1694
Bryan A BassigOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Luoping ZhangDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Roel C VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Services, Utrecht University, Utrecht, The Netherlands.
Wei HuOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Jason Y Y WongOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Chuangyi QiuGuangdong Poison Control Center, Guangzhou, China.
Cuiju WenGuangdong Poison Control Center, Guangzhou, China.
Yongshun HuangGuangdong Poison Control Center, Guangzhou, China.
Mark P PurdueOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Bu-Tian JiOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Laiyu LiGuangdong Poison Control Center, Guangzhou, China.
Xiaojiang TangGuangdong Medical Laboratory Animal Center, Foshan, Guangdong, China.
Nathaniel RothmanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Martyn T SmithDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Qing LanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
National Cancer Institute · USUniversity of California, Berkeley · USJi Hua Laboratory · CNKorea National Open University · KRUtrecht University · NL

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MCHALE, CLIONA · 1987 to 2025
$74.6M
VIROLOGY AND CHRONIC INFECTIONP30ES001896 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1985 to 2003
$4.7M
Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment 2012A061400007Korea National Open University International Research Fund (2018)National Natural Science Foundation of China 81502769NIEHS NIH HHS P30 ES001896NIEHS NIH HHS P42 ES004705
6 · The paper itself

Abstract

objectivesThe objective of our study was to evaluate the association between occupational exposure to trichloroethylene (TCE), a suspected lymphomagen, and serum levels of miRNAs in a cross-sectional molecular epidemiology study of TCE-exposed workers and comparable unexposed controls in China.

methodsSerum levels of 40 miRNAs were compared in 74 workers exposed to TCE (median: 12 ppm) and 90 unexposed control workers. Linear regression models were used to test for differences in serum miRNA levels between exposed and unexposed workers and to evaluate exposure-response relationships across TCE exposure categories using a three-level ordinal variable [i.e., unexposed, < 12 ppm, the median value among workers exposed to TCE) and ≥ 12 ppm)]. Models were adjusted for sex, age, current smoking, current alcohol use, and recent infection.

resultsSeven miRNAs showed significant differences between exposed and unexposed workers at FDR (false discovery rate) < 0.20. miR-150-5p and let-7b-5p also showed significant inverse exposure-response associations with TCE exposure (P

conclusionsmiR-150-5p is involved in B cell receptor pathways and let-7b-5p plays a role in the innate immune response processes that are potentially important in the etiology of non-Hodgkin lymphoma (NHL). Further studies are needed to replicate these findings and to directly test the association between serum levels of these miRNAs and risk of NHL in prospective studies.

Indexed as

Molecular EpidemiologyBiomarkersChinaFemaleHumansMaleMicroRNAsOccupational ExposureTrichloroethyleneBiomarkersMicroRNAsTrichloroethyleneEpigeneticsmicroRNAsTrichloroethylene

Identifiers

PMID31161417
PMCPMC6953905
OpenAlexW2948854149

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.