ArticleExperimental brain research2019
Functional motor control deficits in older FMR1 premutation carriers.
Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Use of the Behavioral Dyscontrol Scale-2 (BDS-2) to measure executive dysfunction in FXTAS.Frontiers in molecular neuroscience · 2026Article
- Prosodic Differences in Women with theInternational journal of molecular sciences · 2025Article
- Effect of Warm-Up Exercise on Functional Regulation of Motor Unit Activation during Isometric Torque Production.Journal of human kinetics · 2024Article
- Review
- Atypical vocal quality in women with the FMR1 premutation: an indicator of impaired sensorimotor control.Experimental brain research · 2023Article
- Optimal time lags from causal prediction model help stratify and forecast nervous system pathology.Scientific reports · 2021Article
- Upper and Lower Limb Movement Kinematics in AgingBrain sciences · 2020Article
- Cerebellar-cortical function and connectivity during sensorimotor behavior in aging FMR1 gene premutation carriers.NeuroImage. Clinical · 2020Article
- Precision Sensorimotor Control in Aging FMR1 Gene Premutation Carriers.Frontiers in integrative neuroscience · 2019Article
- Low normal FMR1 genotype in older adult women: Psychological well-being and motor function.Archives of gerontology and geriatricsArticle
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Individuals with fragile X mental retardation 1 (FMR1) gene premutations are at increased risk for fragile X-associated tremor/ataxia syndrome (FXTAS) during aging. However, it is unknown whether older FMR1 premutation carriers, with or without FXTAS, exhibit functional motor control deficits compared with healthy individuals. The purpose of this study, therefore, was to determine whether older FMR1 premutation carriers exhibit impaired ability to perform functional motor tasks. Eight FMR1 premutation carriers (age: 58.88 ± 8.36 years) and eight age- and sex-matched healthy individuals (60.13 ± 9.25 years) performed (1) a steady isometric force control task with the index finger at 20% of their maximum voluntary contraction (MVC) and; (2) a single-step task. During the finger abduction task, firing rate of multiple motor units of the first dorsal interosseous (FDI) muscle was recorded. Compared with healthy controls, FMR1 premutation carriers exhibited (1) greater force variability (coefficient of variation of force) during isometric force (1.48 ± 1.02 vs. 0.63 ± 0.37%; P = 0.04); (2) reduced firing rate of multiple motor units during steady force, and; (3) reduced velocity of their weight transfer during stepping (156.62 ± 26.24 vs. 191.86 ± 18.83 cm/s; P = 0.01). These findings suggest that older FMR1 premutation carriers exhibit functional motor control deficits that reflect either subclinical issues associated with premutations independent of FXTAS, or prodromal markers of the development of FXTAS.
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