Evidence map›Paper›PMID 31161394›Full record

ArticleMolecular diversity2020

Design, synthesis, antifungal activity, and structure-activity relationship studies of chalcones and hybrid dihydrochromane-chalcones.

Marco Mellado, Luis Espinoza, Alejandro Madrid, Jaime Mella, Eduardo Chávez-Weisser, Katy Diaz, Mauricio Cuellar

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Design of Hybrid Quinoline-Chalcone Compounds AgainstPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marco MelladoFacultad de Ciencias, Instituto de Química, Pontificia Universidad Católica de Valparaíso, Av. Universidad #330, Curauma, Valparaiso, Chile. marco.mellado@pucv.cl.ORCID http://orcid.org/0000-0001-9577-5180
Luis EspinozaDepartamento de Química, Universidad Técnico Federico Santa María, Av. España 1680, Valparaiso, Chile.
Alejandro MadridDepartamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Valparaiso, Chile.
Jaime MellaFacultad de Ciencias, Instituto de Química, Universidad de Valparaíso, Av. Gran Bretaña 1111, Valparaiso, Chile.
Eduardo Chávez-WeisserDepartamento Laboratorios y Estaciones Cuarentenarias, Servicio Agrícola y Ganadero, Ruta 68 #19100 (Km. 12), Pudahuel, Santiago, Chile.
Katy DiazDepartamento de Química, Universidad Técnico Federico Santa María, Av. España 1680, Valparaiso, Chile. katy.diaz@usm.cl.
Mauricio CuellarFacultad de Farmacia, Centro de Investigación Farmacopea Chilena, Universidad de Valparaíso, Av. Gran Bretaña 1093, Valparaiso, Chile.

Funding

Fondo de Fomento al Desarrollo Científico y Tecnológico Postdoctoral Fondecyt grant 3180408Fondo de Fomento al Desarrollo Científico y Tecnológico Programa Formación de Capital Humano Avanzado 21130456Pontificia Universidad Católica de Valparaíso VRIEA-PUCV "37.0/2017".
6 · The paper itself

Abstract

A series of ten chalcones (7a-j) and five new dihydrochromane-chalcone hybrids (7k-o) were synthesized and identified using spectroscopic techniques (IR, NMR, and MS). All compounds were evaluated in vitro against the B. cinerea and M. fructicola phytopathogens that affect a wide range of crops of commercial interest. All compounds were tested against both phytopathogens using the mycelial growth inhibition test, and it was found that two and five compounds had similar activity to that of the positive control for B. cinerea (7a = 43.9, 7c = 45.5, and Captan

Indexed as

Drug DesignQuantitative Structure-Activity RelationshipAntifungal AgentsAscomycotaBotrytisChalconesChemistry Techniques, SyntheticChromansInhibitory Concentration 50Models, MolecularMolecular ConformationAntifungal AgentsChalconesChromans2D-QSARBotrytis cinereaChalconesDihydrochromaneFungicidesMonilinia fructicola

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.