Evidence map›Paper›PMID 31161388›Full record

Trial reportJournal of neurology2019

Parkinson's-adapted cognitive stimulation therapy: feasibility and acceptability in Lewy body spectrum disorders.

Sheree A McCormick, Sabina Vatter, Lesley-Anne Carter, Sarah J Smith, Vasiliki Orgeta, Ellen Poliakoff, Monty A Silverdale, Jason Raw, David J Ahearn, Christine Taylor and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Vitamin D and Calcium Milk Fortification in Pregnant Women with Periodontitis: A Feasibility Trial.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sheree A McCormickDivision of Neuroscience and Experimental Psychology, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-8512-0121
Sabina VatterDivision of Neuroscience and Experimental Psychology, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.
Lesley-Anne CarterDivision of Population Health, Health Services Research & Primary Care, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-1193-8681
Sarah J SmithSchool of Health and Community Studies, Leeds Beckett University, Leeds, UK.ORCID http://orcid.org/0000-0002-1561-9485
Vasiliki OrgetaDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0001-8643-5061
Ellen PoliakoffDivision of Neuroscience and Experimental Psychology, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0003-4975-7787
Monty A SilverdaleSalford Royal NHS Foundation Trust, Salford, UK.ORCID http://orcid.org/0000-0002-3295-6897
Jason RawPennine Acute Hospitals NHS Trust, Oldham, UK.
David J AhearnManchester University NHS Foundation Trust, Manchester, UK.
Christine TaylorDerbyshire Healthcare NHS Foundation Trust, Derby, UK.
Joanne RoddaNorth East London NHS Foundation Trust, London, UK.
Tarek Abdel-GhanyNorth West Boroughs Healthcare NHS Foundation Trust, Winwick, UK.
Benjamin KwapongDivision of Neuroscience and Experimental Psychology, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK.
Iracema LeroiDivision of Neuroscience and Experimental Psychology, University of Manchester, Jean McFarlane Building, Oxford Road, Manchester, M13 9PL, UK. iracema.leroi@tcd.ie.ORCID http://orcid.org/0000-0003-1822-3643

Funding

Department of Health PB-PG-0613-31058Research for Patient Benefit Programme PB-PG-0613-31058
6 · The paper itself

Abstract

backgroundDrug-based therapeutic approaches for Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are moderately effective and not always tolerated. Tailoring psychosocial approaches in PDD and DLB may offer additional support and improve outcomes. We adapted home-based, care partner-delivered Cognitive Stimulation Therapy (CST) for individuals with PDD or DLB and their care partners (CST-PD).

objectivesTo evaluate the feasibility, acceptability, and tolerability of CST-PD.

methodsThis randomised controlled trial used mixed methods, including a process evaluation. People with PDD, DLB or mild cognitive impairment in PD (PD-MCI) and their care partners were randomised to 12 weeks of treatment as usual (TAU) or CST-PD. Outcomes were feasibility of the study conduct (i.e., recruitment, retention rate) and acceptability and tolerability of the intervention. Measures included rating scales, researcher field notes, therapy diaries, and exploratory clinical and care partner efficacy measures.

resultsThe recruitment target was met with 76 consenting participant-dyads. Retention in both arms was high at over 70%. More than 90% of dyads undertook discrete sessions greater than 20 min duration, but the average number of sessions completed was lower than the recommended dose. Acceptability ratings (i.e., interest, motivation and sense of achievement) of the intervention were high. Participants reported no serious adverse events related to the intervention.

conclusionsThe field of psychosocial interventions for PDD and DLB is newly emerging, and we demonstrated that this type of intervention is acceptable and well tolerated. Evaluating its clinical effectiveness in a full-scale randomized controlled clinical trial is warranted. TRIAL REGISTRATION NUMBER: The trial is a psychosocial intervention with an allocated ISRCTN number 11455062.

Indexed as

AgedCognitive Behavioral TherapyFeasibility StudiesFemaleHumansLewy Body DiseaseMaleParkinson DiseasePilot ProjectsSingle-Blind MethodTreatment OutcomeCognitionFeasibilityParkinson’s disease dementiaPsychosocial therapyQuality of life

Identifiers

PMID31161388
PMCPMC6586694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.