Evidence map›Paper›PMID 31161387›Full record

ArticleJournal of neurology2019

The relationship between ischaemic brain lesions and cognitive outcome after aneurysmal subarachnoid haemorrhage.

I M C Huenges Wajer, M E Hendriks, T D Witkamp, J Hendrikse, G J E Rinkel, J M A Visser-Meily, M J E van Zandvoort, M D I Vergouwen, J B de Vis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Spontaneous subarachnoid haemorrhage.Lancet (London, England) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

I M C Huenges WajerDepartment of Neurology and Neurosurgery, G03.232, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. I.M.C.HuengesWajer@umcutrecht.nl.
M E HendriksDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
T D WitkampDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
J HendrikseDepartment of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
G J E RinkelDepartment of Neurology and Neurosurgery, G03.232, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
J M A Visser-MeilyDepartment of Rehabilitation, University Medical Center Utrecht and Center of Excellence in Rehabilitation Medicine, Utrecht University, Rehabilitation Center de Hoogstraat, Utrecht, The Netherlands.
M J E van ZandvoortDepartment of Neurology and Neurosurgery, G03.232, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
M D I VergouwenDepartment of Neurology and Neurosurgery, G03.232, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.
J B de VisNational Institute of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.

Funding

H2020 European Research Council 637024
6 · The paper itself

Abstract

backgroundCerebral ischaemia is thought to be an important determinant of cognitive outcome after aneurysmal subarachnoid haemorrhage (aSAH), but the exact relationship is unclear. We studied the effect of ischaemic brain lesions during clinical course on cognitive outcome 2 months after aSAH.

methodsWe studied 74 consecutive patients admitted to the University Medical Center Utrecht who had MRI post-coiling (3-21 days post-aSAH) and neuropsychological examination at 2 months. An ischaemic lesion was defined as hyperintensity on T2-FLAIR and DWI images. We measured both cognitive complaints (subjective) and cognitive functioning (objective). The relationship between ischaemic brain lesions and cognitive outcome was analysed by logistic regression analyses.

resultsIn 40 of 74 patients (54%), 152 ischaemic lesions were found. The median number of lesions per patient was 2 (1-37) and the median total lesion volume was 0.2 (0-17.4) mL. No difference was found between the group with and the group without ischaemic lesions with respect to the frequency of cognitive complaints. In the group with ischaemic lesions, significantly more patients (55%) showed poor cognitive functioning compared to the group without ischaemic lesions (26%) (OR 3.4, 95% CI 1.3-9.1). We found no relationship between the number and volume of the ischaemic lesions and cognitive functioning.

conclusionsIschaemic brain lesions detected on MRI during clinical course after aSAH is a marker for poor cognitive functioning 2 months after aSAH, irrespective of the number or volume of the ischaemic lesions. Network or connectivity studies are needed to better understand the relationship between location of the ischaemic brain lesions and cognitive functioning.

Indexed as

CognitionAgedBrainBrain IschemiaCognition DisordersFemaleHumansMaleMiddle AgedNeuropsychological TestsProspective StudiesSubarachnoid HemorrhageAneurysmCerebral ischaemiaCognitionMRISubarachnoid haemorrhage

Identifiers

PMID31161387
PMCPMC6689896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.