Evidence map›Paper›PMID 31161339›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Management of antibody-mediated autoimmune encephalitis in adults and children: literature review and consensus-based practical recommendations.

Luigi Zuliani, Margherita Nosadini, Matteo Gastaldi, Marianna Spatola, Raffaele Iorio, Marco Zoccarato, Sara Mariotto, Piera De Gaspari, Francesco Perini, Sergio Ferrari and 4 more

Abstract readReviewConsensus Statement
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Acrodynia and CASPR2 Autoimmunity in Elemental Mercury Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026
    Article
  4. Suspected encephalitis in adults.Practical neurology · 2026
    Review
  5. Article
  6. Autoimmune Encephalitis in Acute Care-Pathology, Diagnosis, and Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Immunotherapy for autoimmune encephalitis.Cell death discovery · 2025
    Review
  11. Article
  12. Recent advances in autoimmune encephalitis.Arquivos de neuro-psiquiatria · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Luigi ZulianiDepartment of Neurology, Ospedale San Bortolo, Azienda ULSS8 Berica, Via Rodolfi 37, 36100, Vicenza, Italy. luigi.zuliani@aulss8.veneto.it.ORCID http://orcid.org/0000-0001-7922-9024
Margherita NosadiniNeuroimmunology Group, Pediatric Research Institute "Città della Speranza", Padova, Italy.
Matteo GastaldiNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Marianna SpatolaInstitut d'Investigacions Biomediques August Pi i Sunyer, Hospital Clınic, University of Barcelona, Barcelona, Spain.
Raffaele IorioDepartment of Neuroscience, Fondazione Policlinico Universitario 'A.Gemelli' IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Marco ZoccaratoNeuroimmunology Group, Pediatric Research Institute "Città della Speranza", Padova, Italy.
Sara MariottoDepartment of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.
Piera De GaspariNeuroimmunology Group, Pediatric Research Institute "Città della Speranza", Padova, Italy.
Francesco PeriniDepartment of Neurology, Ospedale San Bortolo, Azienda ULSS8 Berica, Via Rodolfi 37, 36100, Vicenza, Italy.
Sergio FerrariDepartment of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.
Amelia EvoliDepartment of Neuroscience, Fondazione Policlinico Universitario 'A.Gemelli' IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Stefano SartoriNeuroimmunology Group, Pediatric Research Institute "Città della Speranza", Padova, Italy.
Diego FranciottaNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Bruno GiomettoDepartment of Neurology, Ospedale Santa Chiara, Trento, Italy.
Fondazione Istituto Neurologico Nazionale Casimiro Mondino · ITOspedale San Bortolo · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Padua · ITUniversity of Verona · ITAULSS 2 Marca Trevigiana · ITCittà della Speranza Foundation · ITOspedale Santa Chiara · ITUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune encephalitis associated with antibodies against neuronal surface targets (NSAE) are rare but still underrecognized conditions that affect adult and pediatric patients. Clinical guidelines have recently been published with the aim of providing diagnostic clues regardless of antibody status. These syndromes are potentially treatable but the choice of treatment and its timing, as well as differential diagnoses, long-term management, and clinical and paraclinical follow-up, remain major challenges. In the absence of evidence-based guidelines, management of these conditions is commonly based on single-center expertise.Taking into account different published expert recommendations in addition to the multicenter experience of the Italian Working Group on Autoimmune Encephalitis, both widely accepted and critical aspects of diagnosis, management and particularly of immunotherapy for NSAE have been reviewed and are discussed.Finally, we provide consensus-based practical advice for managing hospitalization and follow-up of patients with NSAE.

Indexed as

AdultAutoantibodiesChildEncephalitisFemaleHashimoto DiseaseHumansMaleAutoantibodiesAutoimmune encephalitisLGI1NMDARNSAbNSAE

Identifiers

PMID31161339
OpenAlexW2948961603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.