Stopping Untreatable Pathogen Infections Using Peptide Ligands to Sabotage Pathogenic Cell Surface Proteins.

Specifically targeted peptide ligands can sabotage pathogenic cell surface proteins and stop increasingly untreatable pathogen infections. Different approaches might be used to sabotage pathogenic cell surface proteins to stop infections. A conjugation treatment uses carefully selected genetically modified plasmids prepared in advance to activate a secondary immune system response neutralizing pathogens with a new, much larger cascade of antibodies. Non-conjugation treatment introduces genetically modified cells into the center of localized pathogen infections to produce peptide ligands; and another non-conjugation treatment introduces only the peptide ligands into the center of localized pathogen infections to sabotage pathogenic cell surface proteins used to specifically infect mammalian cells. Extensive and meticulous plasmid transfer experiments by two separate groups firmly support the feasibility of extremely rapid and thorough plasmid transfer necessary for the conjugation treatment. A third independent group introduced genetically modified bacteria into mammals, including several human volunteers, with safe and effective experimental results, which also firmly supports the feasibility of the first non-conjugation treatment. These three approaches offer several profound advantages compared to treatments using new antibiotics.