ReviewCurrent psychiatry reports2019
Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder.
Review in Current psychiatry reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome.Current neuropharmacology · 2023Trial
- Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.BMC psychiatry · 2026Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Evaluating the efficacy of three classical EEG paradigms in the discrimination of bipolar depression.Frontiers in psychiatry · 2025Article
- Neuroimaging in post-traumatic stress disorder: a narrative review.Archives of medical science : AMS · 2025Article
- Improving Quality of Life in Bipolar Disorders with an Immersive Virtual Reality Remediation Training Randomized Controlled Trial (RCT).Journal of clinical medicine · 2024Article
- Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder.Brain sciences · 2023Article
- Evidence From Imaging Resilience Genetics for a Protective Mechanism Against Schizophrenia in the Ventral Visual Pathway.Schizophrenia bulletin · 2022Article
- A Possible White Matter Compensating Mechanism in the Brain of Relatives of People Affected by Psychosis Inferred from Repeated Long-Term DTI Scans.Schizophrenia bulletin open · 2022Article
- Unstructured Group Support Enhances Compliance to Pharmacological Treatment by Improving Social Cognition in Patients with Bipolar Disorder: A Pilot fMRI Study.Psychiatry and clinical psychopharmacology · 2021Article
- Changes in Intrinsic Brain Connectivity in Family-Focused Therapy Versus Standard Psychoeducation Among Youths at High Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study.Translational psychiatry · 2021Article
- Pre- and Post-treatment Levels of Plasma Metabolites in Patients With Bipolar Depression.Frontiers in psychiatry · 2021Article
- The Discovery of Clinically Applicable Biomarkers for Bipolar Disorder: A Review of Candidate and Proteomic Approaches.Chonnam medical journal · 2020Review
- Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network.Brain sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewFamilial predisposition to bipolar disorder is associated with increased risk of affective morbidity in the first-degree relatives of patients. Nevertheless, a substantial proportion of relatives remain free of psychopathology throughout their lifetime. A series of studies reviewed here were designed to test whether resilience in these high-risk individuals is associated with adaptive brain plasticity. RECENT
findingsThe findings presented here derive from structural and functional magnetic resonance imaging data obtained from patients, their resilient first-degree relatives, and healthy individuals. Patients and relatives showed similar abnormalities in activation and connectivity while performing tasks of interference control and facial affect recognition and in the resting-state connectivity of sensory and motor regions. Resilient relatives manifested unique neuroimaging features that differentiated them from patients and healthy individuals. Specifically, they had larger cerebellar vermis volume, enhanced prefrontal connectivity during task performance, and enhanced functional integration of the default mode network in task-free conditions. Resilience to bipolar disorder is not the reverse of risk but is associated with adaptive brain changes indicative of increased neural reserve. This line of research may open new avenues in preventing and treating bipolar disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.