Evidence map›Paper›PMID 31161210›Full record

ArticleBioinformatics (Oxford, England)2019

eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data.

Charles E Breeze, Alex P Reynolds, Jenny van Dongen, Ian Dunham, John Lazar, Shane Neph, Jeff Vierstra, Guillaume Bourque, Andrew E Teschendorff, John A Stamatoyannopoulos and 1 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 17 syntheses or guidelines pooled it.

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  14. Multi-ancestry genome-wide association study of asthma exacerbations.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Charles E BreezeMedical Genomics Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
Alex P ReynoldsAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Jenny van DongenDepartment of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam 1081BT, The Netherlands.
Ian DunhamEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge CB10 1SD, UK.
John LazarAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Shane NephAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Jeff VierstraAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Guillaume BourqueDepartment of Human Genetics, McGill University and Génome Québec Innovation Center, Montréal H3A 0G1, Canada.
Andrew E TeschendorffCAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
John A StamatoyannopoulosAltius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
Stephan BeckMedical Genomics Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK.

Funding

Wellcome Trust 99148
6 · The paper itself

Abstract

summaryThe Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400 000 new sites. Previously, a method named eFORGE was developed to provide insights into cell type-specific and cell-composition effects for 450k data. Here, we present a significantly updated and improved version of eFORGE that can analyze both EPIC and 450k array data. New features include analysis of chromatin states, transcription factor motifs and DNase I footprints, providing tools for epigenome-wide association study interpretation and epigenome editing. AVAILABILITY AND IMPLEMENTATION: eFORGE v2.0 is implemented as a web tool available from https://eforge.altiusinstitute.org and https://eforge-tf.altiusinstitute.org/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

DNA MethylationEpigenomicsChromatinCpG IslandsDeoxyribonuclease IOligonucleotide Array Sequence AnalysisSoftwareChromatinDeoxyribonuclease I

Identifiers

PMID31161210
PMCPMC6853678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.