ArticleJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2019
Sepsis in Acute Mediastinitis - A Severe Complication after Oesophageal Perforations. A Review of the Literature.
Article in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Impact of early versus late-onset mediastinitis on outcomes after upper gastrointestinal surgery.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025Article
- A Comprehensive Review of Digestive Endoscopy-Associated Infections: Bacterial Pathogens, Host Susceptibility, and the Impact of Viral Hepatitis.Microorganisms · 2025Review
- Management of Deep Neck Infection Associated with Descending Necrotizing Mediastinitis: A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
- Management of an Ingested Foreign Body in a COVID-Positive Patient.Anesthesia progress · 2023Article
- Acute Mediastinitis - Outcomes and Prognostic Factors of Surgical Therapy (A Single-Center Experience).Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2022Article
- Diagnostic challenge and surgical management of Boerhaave's syndrome: a case series.Journal of medical case reports · 2021Article
- Mediastinitis due to Cervical Osteophytes in a Patient after Hemithyroidectomy.Turkish journal of anaesthesiology and reanimation · 2021Article
- Kambo Frog Poison as a Cause of Esophageal Rupture.Cureus · 2020Article
- Management of boerhaave's syndrome in the intensive care unit.International journal of critical illness and injury scienceReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite recent advancements in antibiotic therapy and the progress made in critical care and modern diagnostic methods, acute mediastinitis continues to be a severe condition. DIAGNOSIS AND TREATMENT: Acute mediastinitis can occur in the context of cardio-thoracic surgery, oesophageal perforations and oropharyngeal infections condition. Forty-five percent of oesophageal perforations occurs during simple endoscopy. Spontaneous perforation (Boerhaave syndrome) accounts for 15% of perforations, and twelve percent are due to the ingestion of foreign bodies. Other causes include blind or penetrating trauma, and circa 9% to intraoperative lesions. CT scan is the standard investigation that reveals direct signs of mediastinitis.The oral administration of contrast substances can underscore the level of oesophageal perforation. Conservative treatment is the first-choice treatment and surgical treatment is reserved only for specific situations.The principles of surgical treatment consist of drainage, primary suture, oesophageal exclusion with or without the application of oesophagectomy, endoscopic vacuum wound assisted therapy of the perforation and associated paraoesophageal mediastinal drainage and endoscopic stenting associated with drainage.
conclusionsThe lowest mortality rate is recorded in patients with perforations diagnosed less than twenty-four hours after the onset of symptoms. Surgical treatment remains the gold standard especially in cases of thoracic and abdominal perforations while further investigations are mandatory before endoscopic stenting is carried out.
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