Evidence map›Paper›PMID 31161042›Full record

ArticleMaternal health, neonatology and perinatology2019

Effect of early versus delayed cord clamping in neonate on heart rate, breathing and oxygen saturation during first 10 minutes of birth - randomized clinical trial.

Ashish Kc, Nalini Singhal, Jageshwor Gautam, Nisha Rana, Ola Andersson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal health, neonatology and perinatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
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  5. Review
  6. Observational
  7. Article
  8. Article
  9. South African midwives' knowledge of the benefits of delayed umbilical cord clamping.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Increased risk of bradycardia in vigorous infants receiving early as compared to delayed cord clamping at birth.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Observational
  15. Article
  16. Review
  17. Review
  18. Observational
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Ashish Kc1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-0541-4486
Nalini Singhal2University of Calgary, Calgary, Canada.
Jageshwor GautamParopakar Maternity and Women's hospital, Kathmandu, Nepal.
Nisha Rana1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Ola AnderssonDepartment of Clinical Sciences Lund, Pediatrics/Neonatology, Skane University Hospital, Lund University, Lund, Sweden.
Uppsala University · SELund University · SEUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed cord clamping (DCC) after 180 s reduces iron deficiency up to 8 months of infancy compared to babies who received Early Cord Clamping (ECC) at less than 60 s. Experimentally DCC has shown to improve cardio-vascular stability. To evaluate the effect of delayed (≥180 s) group versus early (≤60 s) cord clamping group on peripheral blood oxygenation and heart rate up to 10 min after birth on term and late preterm infants.

methodsWe conducted a single centred randomized clinical trial in a low risk delivery unit in tertiary Hospital, Nepal. One thousand five hundred ten women, low risk vaginal delivery with foetal heart rate (FHR) ≥ 100 ≤ 160 beats per minute (bpm) and gestational age (≥33 weeks) were enrolled in the study. Participants were randomly assigned to cord clamped ≤60 s of birth and ≥ 180 s. The main outcome measures were oxygen saturation, heart rate from birth to 10 min and time of spontaneous breathing. The oxygen saturation and heart rate, the time of first breath and establishment of regular breathing was analysed using Student t-test to compare groups. We analysed the range of heart rate distributed by different centiles from the time of birth at 30 s intervals until 10 min.

resultsThe oxygen saturation was 18% higher at 1 min, 13% higher at 5 min and 10% higher at 10 min in babies who had cord clamping in delayed group compared to early group (

conclusionSpontaneously breathing babies subjected to DCC have higher oxygen saturation up to 10 min after birth compared to those who have undergone ECC. Spontaneously breathing babies with DCC have lower heart rates compared to ECC until 390 s. Spontaneously breathing babies receiving DCC have early establishment of breathing compared to ECC.

trial registrationISRCTN, 5 April 2016.

Indexed as

Delayed cord clampingHeart rate in first 10 minOxygen saturation in first 10 minRandomized clinical trialSpontaneous breathingTerm and late preterm infants

Identifiers

PMID31161042
PMCPMC6542070
OpenAlexW2946964388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.