Evidence map›Paper›PMID 31161020›Full record

ArticleEcology and evolution2019

Transstadial immune activation in a mosquito: Adults that emerge from infected larvae have stronger antibacterial activity in their hemocoel yet increased susceptibility to malaria infection.

Lisa D Brown, Lillian L M Shapiro, Grayson A Thompson, Tania Y Estévez-Lao, Julián F Hillyer

Open access · goldAbstract read
In one paragraph

Article in Ecology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 47 citations in OpenAlex.

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  13. Trained Immunity inFrontiers in microbiology · 2021
    Article
  14. Article
  15. The legacy of larval infection on immunological dynamics over metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lisa D BrownDepartment of Biological Sciences Vanderbilt University Nashville Tennessee.ORCID https://orcid.org/0000-0001-6314-7729
Lillian L M ShapiroDepartment of Biological Sciences Vanderbilt University Nashville Tennessee.
Grayson A ThompsonDepartment of Biological Sciences Vanderbilt University Nashville Tennessee.
Tania Y Estévez-LaoDepartment of Biological Sciences Vanderbilt University Nashville Tennessee.
Julián F HillyerDepartment of Biological Sciences Vanderbilt University Nashville Tennessee.ORCID https://orcid.org/0000-0002-3178-0201
Vanderbilt University · US

Funding

Effect of mosquito larval infection on adult life history traitsR21AI119596 · NIAID · VANDERBILT UNIVERSITY · PI HILLYER, JULIAN F · 2015 to 2016
$432k
NIAID NIH HHS R21 AI119596
6 · The paper itself

Abstract

Larval and adult mosquitoes mount immune responses against pathogens that invade their hemocoel. Although it has been suggested that a correlation exists between immune processes across insect life stages, the influence that an infection in the hemocoel of a larva has on the immune system of the eclosed adult remains unknown. Here, we used

Indexed as

Anopheles gambiaeCulicidaehemocyteimmunityinsectmalariametamorphosis

Identifiers

PMID31161020
PMCPMC6540708
OpenAlexW2942131428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.