ArticleNature microbiology2019
An expanded subfamily of G-protein-coupled receptor genes in Fusarium graminearum required for wheat infection.
Article in Nature microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 100 citations in OpenAlex.
- Histone Acetylation Dynamics Regulate Fungal Development, Pathogenicity, and Mycotoxin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2026Review
- A conserved fungal Egh16-like effector suppresses host defense by disrupting ATP binding of wheat MPK3.Journal of integrative plant biology · 2026Article
- Interplay between stress granule-like structures and nuclear RNA export in a heat shock-specific manner.Nucleic acids research · 2026Article
- FgCot1 Regulates Polarized Growth and Conidiation in Fusarium graminearum via Gpmk1 MAPK and Tsf1 Transcriptional Pathways.Molecular plant pathology · 2026Article
- Article
- Computational glycosyltransferases masked deoxynivalenol toxicity and halted FHB spread in wheat grains.Journal of advanced research · 2026Article
- H3K27me3-Mediated Epigenetic Silencing of FgHMG1 Enables Fungal Host Immune Evasion.Plant biotechnology journal · 2026Article
- Dissecting G-protein signaling pathways in the fruit pathogen Penicillium expansum: implications for pathogenesis and patulin production.Molecular horticulture · 2026Article
- N6-methyladenine DNA modification modulates pathogen virulence in nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular Strategies and Regulatory Networks in the Early Infection Stages of Plant Pathogenic Fusarium Species.The plant pathology journal · 2026Review
- The role of fungal G protein-coupled receptors in interspecies cell-cell communication.FEMS microbiology reviews · 2026Review
- FgMob1 is involved in mitotic exit and regulates the development, abiotic stress response, and pathogenicity ofFrontiers in plant science · 2026Article
- Wheat Plasma Membrane Receptors: Orchestrating Immunity and Bridging to Crop Improvement.Current issues in molecular biology · 2025Review
- FgNdk1 Promotes Effector Secretion to Scavenge ROS During Fusarium graminearum Infection.Molecular plant pathology · 2025Article
- An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize.Nature plants · 2025Article
- The Mgv1-Rlm1 axis orchestrates SAGA and SWI/SNF complexes at target promoters.Nucleic acids research · 2025Article
- Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete Fusarium graminearum.Nature communications · 2025Article
- Integrative glycomic analysis reveals the crucial role of protein glycosylation in fungal pathogenesis.PLoS pathogens · 2025Article
- The rise of fungal G-protein coupled receptors in pathogenesis and symbiosis.PLoS pathogens · 2025Article
- Unveiling the multifaceted potential ofMicrobiology spectrum · 2024Article
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cAMP-PKA and MAP kinase pathways are essential for plant infection in the wheat head blight fungus Fusarium graminearum. To identify upstream receptors of these well-conserved signalling pathways, we systematically characterized the 105 G-protein-coupled receptor (GPCR) genes. Although none were required for vegetative growth, five GPCR genes (GIV1-GIV5) significantly upregulated during plant infection were important for virulence. The giv1 mutant was defective in the formation of specialized infection structures known as infection cushions, which was suppressed by application of exogenous cAMP and dominant active FST7 MEK kinase. GIV1 was important for the stimulation of PKA and Gpmk1 MAP kinase by compounds in wheat spikelets. GIV2 and GIV3 were important for infectious growth after penetration. Invasive hyphae of the giv2 mutant were defective in cell-to-cell spreading and mainly grew intercellularly in rachis tissues. Interestingly, the GIV2-GIV5 genes form a phylogenetic cluster with GIV6, which had overlapping functions with GIV5 during pathogenesis. Furthermore, the GIV2-GIV6 cluster is part of a 22-member subfamily of GPCRs, with many of them having in planta-specific upregulation and a common promoter element; however, only three subfamily members are conserved in other fungi. Taken together, F. graminearum has an expanded subfamily of infection-related GPCRs for regulating various infection processes.
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