Evidence map›Paper›PMID 31160698›Full record

ArticleScientific reports2019

A Novel Small RNA-Cleaving Deoxyribozyme with a Short Binding Arm.

Yueyao Wang, Jintao Yang, Xin Yuan, Jin Cao, Jiacui Xu, John C Chaput, Zhe Li, Hanyang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yueyao WangMedical School of Nanjing University, Nanjing, 210093, China.
Jintao YangDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Hankou Road, No. 22, Nanjing, 210093, China.
Xin YuanState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Xianlin Road, No. 163, Nanjing, 210023, China.
Jin CaoDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Hankou Road, No. 22, Nanjing, 210093, China.
Jiacui XuCollege of Animal Sciences, Jilin University, Xi'an Road No. 5333, Changchun, 130062, China.
John C ChaputDepartment of Pharmaceutical Sciences, Department of Chemistry, and Department of Molecular Biology and Biochemistry, University of California, Irvine, California, 92697-3958, United States.
Zhe LiDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Hankou Road, No. 22, Nanjing, 210093, China. zheli@nju.edu.cn.
Hanyang YuDepartment of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Hankou Road, No. 22, Nanjing, 210093, China. hanyangyu@nju.edu.cn.ORCID http://orcid.org/0000-0003-1257-1735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deoxyribozymes capable of catalyzing sequence-specific RNA cleavage have found broad applications in biotechnology, DNA computing and environmental sensing. Among these, deoxyribozyme 8-17 is the most common small DNA motif capable of catalyzing RNA cleavage. However, the extent to which other DNA molecules with similar catalytic motifs exist remains elusive. Here we report a novel RNA-cleaving deoxyribozyme called 10-12opt that functions with an equally small catalytic motif and an unusually short binding arm. This deoxyribozyme contains a 14-nucleotide catalytic core that preferentially catalyzes RNA cleavage at UN dinucleotide junctions (k

Indexed as

RNA CleavageAdenosine TriphosphateBase SequenceDNA, CatalyticHydrogen-Ion ConcentrationIonsKineticsMetalsMicroRNAsMutagenesisMutationSubstrate SpecificityAdenosine TriphosphateDNA, CatalyticIonsMetalsMicroRNAsRNA-cleaving DNA 8-17

Identifiers

PMID31160698
PMCPMC6546695

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.