ArticleMolecular psychiatry2021
Familial risk and heritability of diagnosed borderline personality disorder: a register study of the Swedish population.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- The economic burden of Borderline Personality Disorder: direct and indirect costs, and evidence from evaluations of interventions.Frontiers in psychiatry · 2026Pooled it
- Gonadal hormones in borderline personality disorder: implications for understanding symptoms and supporting treatment.Archives of women's mental health · 2024Pooled it
- A randomised study and an extension study of brexpiprazole in patients with borderline personality disorder.Acta neuropsychiatrica · 2024Trial
- Central nervous system acting medication used by young adults with borderline personality disorder in Sweden 2006-2019.Journal of psychopharmacology (Oxford, England) · 2026Article
- Demographic and clinical profiles of drug-induced psychosis: age, gender, and social context in a German cohort.European archives of psychiatry and clinical neuroscience · 2026Article
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Article
- Borderline personality disorder and other psychiatric, somatic, and behavioral conditions: a nationwide family study.Translational psychiatry · 2026Article
- Neural Correlates of Social Exclusion and Childhood Trauma in Borderline Personality Disorder.Cureus · 2025Article
- Investigation of Optic Nerve Sheath Diameter, Intraocular Pressure, and Dry Eye in Patients with Borderline Personality Disorder: The Role of Childhood Trauma.Journal of clinical medicine · 2025Article
- Understanding the Borderline Brain: A Review of Neurobiological Findings in Borderline Personality Disorder (BPD).Biomedicines · 2025Review
- Borderline personality: revisiting its classification as a neurodevelopmental disorder.Frontiers in psychiatry · 2025Review
- Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations.Journal of clinical medicine · 2024Review
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- Treating depression in patients with borderline personality disorder: clinical clues on the use of antidepressants.Annals of general psychiatry · 2024Review
- The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.Borderline personality disorder and emotion dysregulation · 2024Article
- Borderline personality disorder: a comprehensive review of diagnosis and clinical presentation, etiology, treatment, and current controversies.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Twenty years of research on borderline personality disorder: a scientometric analysis of hotspots, bursts, and research trends.Frontiers in psychiatry · 2024Review
- Evidence for a shared genetic contribution to loneliness and borderline personality disorder.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Family and twin studies of Borderline Personality Disorder (BPD) have found familial aggregation and genetic propensity for BPD, but estimates vary widely. Large-scale family studies of clinically diagnosed BPD are lacking. Therefore, we performed a total-population study estimating the familial aggregation and heritability of clinically diagnosed BPD. We followed 1,851,755 individuals born 1973-1993 in linked Swedish national registries. BPD-diagnosis was ascertained between 1997 and 2013, 11,665 received a BPD-diagnosis. We identified relatives and estimated sex and birth year adjusted hazard ratios, i.e., the rate of BPD-diagnoses in relatives to individuals with BPD-diagnosis compared to individuals with unaffected relatives, and used structural equation modeling to estimate heritability. The familial association decreased along with genetic relatedness. The hazard ratio was 11.5 (95% confidence interval (CI) = 1.6-83.8) for monozygotic twins; 7.4 (95% CI = 1.0-55.3) for dizygotic twins; 4.7 (95% CI = 3.9-5.6) for full siblings; 2.1 (95% CI = 1.5-3.0) for maternal half-siblings; 1.3 (95% CI = 0.9-2.1) for paternal half-siblings; 1.7 (95% CI = 1.4-2.0) for cousins whose parents were full siblings; 1.1 (95% CI = 0.7-1.8) for cousins whose parents were maternal half-siblings; and 1.9 (95% CI = 1.2-2.9) for cousins whose parents were paternal half-siblings. Heritability was estimated at 46% (95% CI = 39-53), and the remaining variance was explained by individually unique environmental factors. Our findings pave the way for further research into specific genetic variants, unique environmental factors implicated, and their interplay in risk for BPD.
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