ArticleScientific reports2019
In-feed bacitracin methylene disalicylate modulates the turkey microbiota and metabolome in a dose-dependent manner.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Discovery of BilV reveals a multienzymatic basis for bilirubin reduction across vertebrate gut microbiomes.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of antibiotic usage during late gestation on pelvic organ prolapse incidence in sows.Translational animal science · 2026Article
- In-vitro assessment of probiotic potential of bacteria isolated from chicken gastrointestinal tract.Antonie van Leeuwenhoek · 2025Article
- Temporal dynamics of fecal microbiota community succession in broiler chickens, calves, and piglets under aerobic exposure.Microbiology spectrum · 2024Article
- Exploring the complexities of poultry respiratory microbiota: colonization, composition, and impact on health.Animal microbiome · 2024Review
- Bacitracin Methylene Disalicylate (BMD) Treatment Affects Spleen Proteome in Broiler Chicks Infected withAntibiotics (Basel, Switzerland) · 2024Article
- The improvement of immunity and activation of TLR2/NF-κB signaling pathway by Romboutsia ilealis in broilers.Journal of animal science · 2024Article
- Intestinal Damages by F18Antioxidants (Basel, Switzerland) · 2023Article
- Identification and characterization of the causative agents of Focal Ulcerative Dermatitis in commercial laying hens.Frontiers in veterinary science · 2023Article
- Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome.Communications biology · 2022Article
- Increased Microbial Diversity and Decreased Prevalence of Common Pathogens in the Gut Microbiomes of Wild Turkeys Compared to Domestic Turkeys.Applied and environmental microbiology · 2022Article
- How to employ metabolomic analysis to research on functions of prebiotics and probiotics in poultry gut health?Frontiers in microbiology · 2022Review
- Article
- Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.Animals : an open access journal from MDPI · 2021Review
- Typhlitis induced by Histomonas meleagridis affects relative but not the absolute Escherichia coli counts and invasion in the gut in turkeys.Veterinary research · 2021Article
- Convergence of the turkey gut microbiota following cohabitation under commercial settings.Journal of animal science and biotechnology · 2021Article
- A porcine ligated loop model reveals new insight into the host immune response againstGut microbes · 2020Article
- Complete Genome Sequence and Annotation for Turicibacter sanguinis MOL361Microbiology resource announcements · 2020Article
- Complete Genome Sequence and Annotation forMicrobiology resource announcements · 2020Article
- Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens.Journal of animal science and biotechnology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beginning in 2017, the subtherapeutic use of most antibiotic compounds for growth promotion in food producing animals in the US was prohibited, highlighting the need to discover alternative growth promotants. Identifying the mechanism of action of growth promoting antibiotics may aid in the discovery of antibiotic alternatives. We describe the effects of feeding a subtherapeutic (50 g/ton of feed) and therapeutic (200 g/ton) concentration of bacitracin methylene disalicylate (BMD) to commercial turkeys for 14 weeks, and its effect on turkey intestinal microbial communities and cecal metabolomes. Both BMD concentrations had an immediate and lasting impact on the microbiota structure, and reduced bacterial richness through the end of the study (12 weeks). Metabolomic analysis identified 712 biochemicals, and 69% of metabolites were differentially present in BMD treated turkeys for at least one time point (q < 0.1). Amino acids, carbohydrates, nucleotides, peptides, and lipids were decreased in the turkey ceca early after BMD administration. Long-term metabolome alterations continued even after withdrawal of BMD. The microbial composition, determined by 16S rRNA gene sequencing, was predictive of the metabolome, indicating a connection between the microbiome and metabolome. In-feed BMD may cause bacterial metabolic shifts, leading to beneficial traits that can be targeted to improve animal health and production.
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Registered trials
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