ArticleNature communications2019
Low-energy electrons transform the nimorazole molecule into a radiosensitiser.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 66 citations in OpenAlex.
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- Cluster Anions of Hydrated Polycyclic Aromatic Hydrocarbons: "Magic" Water Tetramer.The journal of physical chemistry. A · 2026Article
- Nanosensitizer for enhanced radiotherapy via tumor microenvironment reshaping and ROS amplification.Theranostics · 2026Article
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- Electron Transfer and Negative Ion Formation.The journal of physical chemistry letters · 2025Review
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- Nitro-Group π System Drives the Interaction of RRx-001 with Electrons in Solution.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Electron Attachment to Nitric Oxide (NO) Controversy.The journal of physical chemistry. A · 2025Article
- Asymmetrically PEGylated and amphipathic heptamethine indocyanine dyes potentiate radiotherapy of renal cell carcinoma via mitochondrial targeting.Journal of nanobiotechnology · 2024Article
- Low-Energy Electron Interactions with Methyl-p-benzoquinone: A Study of Negative Ion Formation.ACS omega · 2024Article
- Unraveling the Complexity of DNA Radiation Damage Using DNA Nanotechnology.Accounts of chemical research · 2024Article
- Dissociative Electron Attachment to 5-Iodo-4-thio-2'-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells.The journal of physical chemistry letters · 2023Article
- Electron Scattering from 1-Methyl-5-Nitroimidazole: Cross-Sections for Modeling Electron Transport through Potential Radiosensitizers.International journal of molecular sciences · 2023Article
- Decomposition of triazole and 3-nitrotriazole upon low-energy electron attachment.Physical chemistry chemical physics : PCCP · 2023Article
- Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2'-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment.International journal of molecular sciences · 2023Article
- Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage.Journal of the American Chemical Society · 2023Article
- Electron Energy Loss Processes in Methyl Methacrylate: Excitation and Bond Breaking.The journal of physical chemistry. A · 2023Article
- Parent anion radical formation in coenzyme QComputational and structural biotechnology journal · 2023Article
- Electron attachment to fluorodeoxyglucose: Dissociation dynamics in a molecule of near-zero electron affinity.The Journal of chemical physics · 2022Article
- Electron Attachment to 5-Fluorouracil: The Role of Hydrogen Fluoride in Dissociation Chemistry.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 5 countries.
Funding
Abstract
While matter is irradiated with highly-energetic particles, it may become chemically modified. Thereby, the reactions of free low-energy electrons (LEEs) formed as secondary particles play an important role. It is unknown to what degree and by which mechanism LEEs contribute to the action of electron-affinic radiosensitisers applied in radiotherapy of hypoxic tumours. Here we show that LEEs effectively cause the reduction of the radiosensitiser nimorazole via associative electron attachment with the cross-section exceeding most of known molecules. This supports the hypothesis that nimorazole is selectively cytotoxic to tumour cells due to reduction of the molecule as prerequisite for accumulation in the cell. In contrast, dissociative electron attachment, commonly believed to be the source of chemical activity of LEEs, represents only a minor reaction channel which is further suppressed upon hydration. Our results show that LEEs may strongly contribute to the radiosensitising effect of nimorazole via associative electron attachment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.