Evidence map›Paper›PMID 31160572›Full record

ArticleNature communications2019

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8

Branca I Pereira, Oliver P Devine, Milica Vukmanovic-Stejic, Emma S Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J Sebire, Veronica Kinsler, Alexis Valdovinos and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 354 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
354citing papers in PubMed, 2 pooled it
21.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

354 citing papers in PubMed, 2 syntheses or guidelines pooled it, 510 citations in OpenAlex.

  1. Pooled it
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  14. Article
  15. Interleukin-8 in health and disease.Molecular biomedicine · 2026
    Review
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294 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Branca I PereiraDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Oliver P DevineDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Milica Vukmanovic-StejicDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Emma S ChambersDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.ORCID http://orcid.org/0000-0003-0990-8835
Priya SubramanianDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Neil PatelDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Alex VirasamiInstitute of Histopathology, Great Ormond Street Hospital for Children, University College London, London, WC1N 3JH, UK.ORCID http://orcid.org/0000-0003-1861-9357
Neil J SebireInstitute of Histopathology, Great Ormond Street Hospital for Children, University College London, London, WC1N 3JH, UK.
Veronica KinslerPaediatric Dermatology Department, Great Ormond Street Hospital for Children, University College London, London, WC1N 3JH, UK.
Alexis ValdovinosBuck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Claude Jourdan LeSauxBuck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
João F PassosInstitute for Cell and Molecular Biosciences & Newcastle University Institute for Ageing, Newcastle upon Tyne, NE1 7RU, UK.
Antony AntoniouDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle Upon Tyne, NE1 8ST, UK.
Malcom H A RustinDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Judith CampisiBuck Institute for Research on Aging, 8001 Redwood Blvd, Novato, CA, 94945, USA.
Arne N AkbarDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK. a.akbar@ucl.ac.uk.
University College London · GBBuck Institute for Research on Aging · USGreat Ormond Street Hospital · GBInstitute of Infection and Immunity · CAMayo Clinic · USNorthumbria University · GB

Funding

Cellular Senescence, astrocytes and Alzheimer's diseaseR01AG051729 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI CAMPISI, JUDITH · 2016 to 2020
$2.7M
Characterization of the Various Senescent Cells in the Aging LungsR21AG052744 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LE SAUX, CLAUDE · 2016 to 2017
$436k
Biotechnology and Biological Sciences Research Council BB/H022384/1Medical Research Council MR/M003833/1Medical Research Council MR/N017749/1Medical Research Council MR/P00184X/1NIA NIH HHS R01 AG051729NIA NIH HHS R21 AG052744
6 · The paper itself

Abstract

Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express the non-classical MHC molecule HLA-E, which interacts with the inhibitory receptor NKG2A expressed by NK and highly differentiated CD8

Indexed as

AdultAgedAgingCD8-Positive T-LymphocytesCellular SenescenceCytokinesDermisFibroblastsHistocompatibility Antigens Class IHLA-E AntigensHumansIn Vitro TechniquesKiller Cells, NaturalNevus, PigmentedNK Cell Lectin-Like Receptor Subfamily Cp38 Mitogen-Activated Protein KinasesCytokinesHistocompatibility Antigens Class IHLA-E AntigensNK Cell Lectin-Like Receptor Subfamily Cp38 Mitogen-Activated Protein KinasesRNA, Small Interfering

Identifiers

PMID31160572
PMCPMC6547655
OpenAlexW2948309692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.