Evidence map›Paper›PMID 31160559›Full record

ArticleNature communications2019

Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.

Rathan Joy Komban, Anneli Strömberg, Adi Biram, Jakob Cervin, Cristina Lebrero-Fernández, Neil Mabbott, Ulf Yrlid, Ziv Shulman, Mats Bemark, Nils Lycke

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
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  8. Review
  9. Article
  10. Article
  11. Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Metabolic fitness of IgAMucosal immunology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Rathan Joy KombanMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden.
Anneli StrömbergMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden.
Adi BiramDepartment of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel.ORCID http://orcid.org/0000-0001-6169-9861
Jakob CervinMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden.
Cristina Lebrero-FernándezMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden.
Neil MabbottThe Roslin Institute, Edinburgh University, Edinburgh, EH25 9RG, Scotland.ORCID http://orcid.org/0000-0001-7395-1796
Ulf YrlidMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden.
Ziv ShulmanDepartment of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel.ORCID http://orcid.org/0000-0002-9604-212X
Mats BemarkMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden. mats.bemark@immuno.gu.se.ORCID http://orcid.org/0000-0001-7416-9819
Nils LyckeMucosal Immunobiology and Vaccine Center (MIVAC), Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, S405 30, Sweden. nils.lycke@microbio.gu.se.
University of Gothenburg · SEInstitut de Recherche Vaccinale · FRWeizmann Institute of Science · ILRoslin Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The germinal center (GC) reaction in Peyer's patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6

Indexed as

AnimalsAntigen-Presenting CellsAntigensB-LymphocytesDendritic CellsEpithelial CellsGerminal CenterImmunoglobulin ALymphocyte ActivationMicePeyer's PatchesReceptors, Antigen, B-CellAntigensImmunoglobulin AReceptors, Antigen, B-Cell

Identifiers

PMID31160559
PMCPMC6547658
OpenAlexW2948351213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.