ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Functional Involvement of Human Periaqueductal Gray and Other Midbrain Nuclei in Cognitive Control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Oxytocin, cortisol, and cognitive control during acute and naturalistic stress.Stress (Amsterdam, Netherlands) · 2021Trial
- Modality-specific reactive and predictive responses in the human superior colliculus.Nature neuroscience · 2026Article
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- Histamine shapes the neurocomputational dynamics of human learning.Nature communications · 2026Article
- The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in Mice.bioRxiv : the preprint server for biology · 2026Article
- Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity.Communications biology · 2025Article
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- Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Noncortical cognition: integration of information for close-proximity behavioral problem-solving.Current opinion in behavioral sciences · 2024Article
- Mechanisms of Action of TMS in the Treatment of Depression.Current topics in behavioral neurosciences · 2024Review
- Attention Circuits Mediate the Connection between Emotional Experience and Expression within the Emotional Circuit.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Article
- No evidence for discontinuity between infants and adults.Trends in cognitive sciences · 2023Article
- BTRX-246040 Acts Through the Ventrolateral Periaqueductal Gray to Exert Antidepressant-Relevant Actions in Mice.The international journal of neuropsychopharmacology · 2023Article
- Context reconsidered: Complex signal ensembles, relational meaning, and population thinking in psychological science.The American psychologist · 2022Article
- Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion.Annual review of clinical psychology · 2022Review
- A 7-Tesla MRI study of the periaqueductal gray: resting state and task activation under threat.Social cognitive and affective neuroscience · 2022Article
- Involvement of the intrinsic functional network of the red nucleus in complex behavioral processing.Cerebral cortex communications · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Recent theoretical advances have motivated the hypothesis that the periaqueductal gray (PAG) participates in behaviors that involve changes in the autonomic control of visceromotor activity, including during cognitively demanding tasks. We used ultra-high-field (7 tesla) fMRI to measure human brain activity at 1.1 mm resolution while participants completed a working memory task. Consistent with prior work, participants were less accurate and responded more slowly with increasing memory load-signs of increasing task difficulty. Whole-brain fMRI analysis revealed increased activity in multiple cortical areas with increasing working memory load, including frontal and parietal cortex, dorsal cingulate, supplementary motor area, and anterior insula. Several dopamine-rich midbrain nuclei, such as the substantia nigra and ventral tegmental area, also exhibited load-dependent increases in activation. To investigate PAG involvement during cognitive engagement, we developed an automated method for segmenting and spatially normalizing the PAG. Analyses using cross-validated linear support vector machines showed that the PAG discriminated high versus low working memory load conditions with 95% accuracy in individual subjects based on activity increases in lateral and ventrolateral PAG. Effect sizes in the PAG were comparable in magnitude to those in many of the cortical areas. These findings suggest that cognitive control is not only associated with cortical activity in the frontal and parietal lobes, but also with increased activity in the subcortical PAG and other midbrain regions involved in the regulation of autonomic nervous system function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.