Evidence map›Paper›PMID 31160488›Full record

ReviewBioscience reports2019

The emerging role of circular RNAs in breast cancer.

Si-Ying Zhou, Wei Chen, Su-Jin Yang, Zi-Han Xu, Jia-Hua Hu, He-da Zhang, Shan-Liang Zhong, Jin-Hai Tang

Open access · goldAbstract readReview
In one paragraph

Review in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Promising predictive molecular biomarkers for cervical cancer (Review).International journal of molecular medicine · 2024
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. The promising role and prognostic value of miR-198 in human diseases.American journal of translational research · 2022
    Article
  12. Article
  13. Circular RNAMolecular therapy oncolytics · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Emerging Roles of Circular RNAs in Thyroid Cancer.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Si-Ying ZhouThe First Clinical Medical College, Nanjing University of Chinese Medicine, Xianlin Road 138, Nanjing 210023, P.R. China.
Wei ChenDepartment of Head and Neck Surgery, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China.
Su-Jin YangThe First Clinical School, Nanjing Medical University, Nanjing 210029, P.R. China.
Zi-Han XuDepartment of Integrated Traditional and Western Medicine, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, P.R. China.
Jia-Hua HuThe Fourth Clinical School, Nanjing Medical University, Nanjing 210029, P.R. China.
He-da ZhangDepartment of General Surgery, School of Medicine, Southeast University, 87 Ding Jia Qiao, Nanjing 210009, P.R. China.
Shan-Liang ZhongCenter of Clinical Laboratory Science, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing 210029, P.R. China slzhong@foxmail.com jhtang@njmu.edu.cn.
Jin-Hai TangThe First Clinical Medical College, Nanjing University of Chinese Medicine, Xianlin Road 138, Nanjing 210023, P.R. China slzhong@foxmail.com jhtang@njmu.edu.cn.ORCID 0000-0003-2016-4216
Jiangsu Cancer Hospital · CNNanjing University of Chinese Medicine · CNNanjing General Hospital of Nanjing Military Command · CNNanjing Medical University · CNSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BCa) is one of the most frequently diagnosed cancers and leading cause of cancer deaths among females worldwide. Circular RNAs (circRNAs) are a new class of endogenous regulatory RNAs characterized by circular shape resulting from covalently closed continuous loops that are capable of regulating gene expression at transcription or post-transcription levels. With the unique structures, circRNAs are resistant to exonuclease RNase R and maintain stability more easily than linear RNAs. Recently, an increasing number of circRNAs are discovered and reported to show different expression in BCa and these dysregulated circRNAs were correlated with patients' clinical characteristics and grade in the progression of BCa. CircRNAs participate in the bioprocesses of carcinogenesis of BCa, including cell proliferation, apoptosis, cell cycle, tumorigenesis, vascularization, cell invasion, migration as well as metastasis. Here we concentrated on biogenesis and function of circRNAs, summarized their implications in BCa and discussed their potential as diagnostic and therapeutic targets for BCa.

Indexed as

ApoptosisCell CycleBreast NeoplasmsCarcinogenesisFemaleHumansNeoplasm InvasivenessNeoplasm MetastasisNeoplasm ProteinsNeovascularization, PathologicRibonuclease PRNA, CircularRNA, NeoplasmRNA StabilityNeoplasm ProteinsRibonuclease PRNA, CircularRNA, NeoplasmbiomarkerBreast cancer (BCa)circRNAmiRNA sponge

Identifiers

PMID31160488
PMCPMC6591565
OpenAlexW2948642588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.