ArticleJournal of muscle research and cell motility1987
Metavinculin and vinculin from mammalian smooth muscle: bulk isolation and characterization.
Article in Journal of muscle research and cell motility, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences.Structure (London, England : 1993) · 2019Article
- Conformational states during vinculin unlocking differentially regulate focal adhesion properties.Scientific reports · 2018Article
- Mechanisms and Functions of Vinculin Interactions with Phospholipids at Cell Adhesion Sites.The Journal of biological chemistry · 2016Review
- Actomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring.Nature communications · 2014Article
- The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.The Journal of cell biology · 2012Article
- Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins.The Journal of cell biology · 2001Article
- Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells.The Journal of cell biology · 1999Article
- Identification of the vinculin-binding site in the cytoskeletal protein alpha-actinin.The Biochemical journal · 1994Article
- Complementary distributions of vinculin and dystrophin define two distinct sarcolemma domains in smooth muscle.The Journal of cell biology · 1993Article
- Simple and rapid method for purification of vinculin from bovine aorta.Journal of muscle research and cell motility · 1990Article
- Identification of two distinct functional domains on vinculin involved in its association with focal contacts.The Journal of cell biology · 1989Article
- Porcine vinculin and metavinculin differ by a 68-residue insert located close to the carboxy-terminal part of the molecule.The EMBO journal · 1988Article
- Immunolocalization of meta-vinculin in human smooth and cardiac muscles.The Journal of cell biology · 1988Article
- Interaction of the cytoskeleton with the plasma membrane.The Journal of membrane biology · 1987Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metavinculin, a vinculin related protein found only in muscle, has been prepared in bulk amounts from porcine stomach by a new procedure: the same procedure is applicable to the purification of vinculin from porcine stomach and avian gizzard. A comparison of the mammalian and avian proteins by peptide mapping showed them all to contain a common protease resistant 90 kDa core; however both avian and mammalian vinculins were notably more resistant to proteolysis down to this core than their respective metavinculins. Despite the close similarities in the peptide maps, in molecular weight and amino acid composition neither of the mammalian proteins exhibited the head and tail morphology formerly described for gizzard vinculin and metavinculin; both porcine proteins appeared globular under the electron microscope. From the gross variability in the ratios of metavinculin to vinculin among smooth muscles of different origin as well as from the common detergent-independent solubility properties of both proteins during isolation, it is concluded that vinculin and metavinculin perform duplicatory roles as peripheral membrane components. No definitive evidence for the interaction of either protein with actin filaments was obtained.
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