Evidence map›Paper›PMID 31160363›Full record

ArticleInfection and immunity2019

Caspase-11 Contributes to Oviduct Pathology during Genital

John Allen, Clare E Gyorke, Manoj K Tripathy, Yugen Zhang, Angela Lovett, Stephanie A Montgomery, Uma M Nagarajan

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Complete deletion of theInfection and immunity · 2025
    Article
  2. Plasmid-mediated virulence inFrontiers in cellular and infection microbiology · 2023
    Review
  3. Epithelial Pyroptosis in Host Defense.Journal of molecular biology · 2022
    Review
  4. Article
  5. Review
  6. Infection and immunity · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

John AllenDepartment of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Clare E Gyorke *Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Manoj K Tripathy *Department of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Yugen ZhangDepartment of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Angela LovettDepartment of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Uma M NagarajanDepartment of Pediatrics, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA nagaraja@email.unc.edu.
University of North Carolina at Chapel Hill · USUNC Lineberger Comprehensive Cancer Center

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Targeting the MEKK2-ERK5 Signaling Node in Triple Negative Breast CancerU54CA156733 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURRIDGE, KEITH · 2010 to 2020
$9.7M
Molecular Mechanisms of Type I IFN Induction during Chlamydia InfectionR01AI067678 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2007 to 2018
$3.5M
IRF3 is a novel mediator of cell death during genital Chlamydia infection.R21AI124010 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2016 to 2017
$418k
NCI NIH HHS P30 CA016086NCI NIH HHS U54 CA156733NIAID NIH HHS R01 AI067678NIAID NIH HHS R21 AI124010NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

It has been shown that caspase-1, but not its upstream activator, ASC, contributes to oviduct pathology during mouse genital

Indexed as

AnimalsCaspase 1CaspasesCaspases, InitiatorChlamydia InfectionsFemaleMiceMice, Inbred C57BLNeutrophil InfiltrationOviductsReproductive Tract InfectionsCasp1 protein, mouseCasp4 protein, mouseCaspase 1CaspasesCaspases, Initiatorcaspase-11Chlamydia trachomatisoviduct pathology

Identifiers

PMID31160363
PMCPMC6652777
OpenAlexW2947827877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.