Evidence map›Paper›PMID 31160281›Full record

ArticleAntimicrobial agents and chemotherapy2019

Nonnucleoside Reverse Transcriptase Inhibitor Hypersusceptibility and Resistance by Mutation of Residue 181 in HIV-1 Reverse Transcriptase.

John P Barnard, Kelly D Huber, Nicolas Sluis-Cremer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John P BarnardDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kelly D HuberDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Nicolas Sluis-CremerDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA nps2@pitt.edu.

Funding

NNRTI induced conformational changes in HIV-1 RT - Equipment SupplementR01GM068406 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2003 to 2017
$3.7M
Novel mechanisms of HIV resistance to RTIsR01AI081571 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SLUIS-CREMER, NICOLAS PAUL · 2009 to 2018
$3.0M
NIAID NIH HHS R01 AI081571NIGMS NIH HHS R01 GM068406
6 · The paper itself

Abstract

Substitutions at residue Y181 in HIV-1 reverse transcriptase (RT), in particular, Y181C, Y181I, and Y181V, are associated with nonnucleoside RT inhibitor (NNRTI) cross-resistance. In this study, we used kinetic and thermodynamic approaches, in addition to molecular modeling, to gain insight into the mechanisms by which these substitutions confer resistance to nevirapine (NVP), efavirenz (EFV), and rilpivirine (RPV). Using pre-steady-state kinetics, we found that the dissociation constant (

Indexed as

AlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesDrug Resistance, ViralFluorescence PolarizationHIV-1HIV Reverse TranscriptaseHumansMutationNevirapineReverse Transcriptase InhibitorsRilpivirineAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesefavirenzHIV Reverse TranscriptaseNevirapinereverse transcriptase, Human immunodeficiency virus 1Reverse Transcriptase InhibitorsRilpivirineHIVmechanisms of resistanceNNRTIreverse transcriptase

Identifiers

PMID31160281
PMCPMC6658764

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.