Evidence map›Paper›PMID 31160203›Full record

ReviewThe Lancet. Neurology2019

Migraine and the trigeminovascular system-40 years and counting.

Messoud Ashina, Jakob Møller Hansen, Thien Phu Do, Agustin Melo-Carrillo, Rami Burstein, Michael A Moskowitz

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Lancet. Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07340788 (Amylin-Induced Migraine Attacks Without Aura), which is not on this map. Cited by 294 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
294citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07340788 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Amylin-Induced Migraine Attacks Without Aura: A Randomized Clinical Trial

TypeinterventionalSponsorDanish Headache CenterRan2026 to 2028Enrolled21ConditionsHeadache Disorders, Primary, Headache Disorders, Brain Diseases, Nervous System DiseasesArmsAmylin, Placebo
3 · Its place in the literature

Who cites it

294 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  17. Hypersensitivity to BKThe journal of headache and pain · 2024
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234 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Messoud AshinaDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: ashina@dadlnet.dk.
Jakob Møller HansenDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thien Phu DoDanish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Agustin Melo-CarrilloDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Rami BursteinDepartment of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Michael A MoskowitzDepartment of Neurology and Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

Funding

Photophobia during migraine: sensory, autonomic and emotional responses to lightR37NS079678 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BURSTEIN, RAMI · 2012 to 2018
$3.1M
Cortical Mechanisms of Headache: Beyond CSDR01NS094198 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BURSTEIN, RAMI · 2016 to 2020
$1.9M
NINDS NIH HHS R01 NS094198NINDS NIH HHS R37 NS079678
6 · The paper itself

Abstract

The underlying causes of migraine headache remained enigmatic for most of the 20th century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the neuropeptide-containing trigeminal nerve. This hypothesis led to a transformation in the migraine field and understanding of key concepts surrounding migraine, including the role of neuropeptides and their release from meningeal trigeminal nerve endings in the mechanism of migraine, blockade of neuropeptide release by anti-migraine drugs, and activation and sensitisation of trigeminal afferents by meningeal inflammatory stimuli and upstream role of intense brain activity. The study of neuropeptides provided the first evidence that antisera directed against calcitonin gene-related peptide (CGRP) and substance P could neutralise their actions. Successful therapeutic strategies using humanised monoclonal antibodies directed against CGRP and its receptor followed from these findings. Nowadays, 40 years after the initial proposal, the trigeminovascular system is widely accepted as having a fundamental role in this highly complex neurological disorder and provides a road map for future migraine therapies.

Indexed as

Cardiovascular SystemHumansMigraine DisordersNeural PathwaysTrigeminal Nerve

Identifiers

PMID31160203
PMCPMC7164539

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.