Evidence map›Paper›PMID 31160146›Full record

Trial reportDrug and alcohol dependence2019

Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent.

Aaron C Lim, Dara G Ghahremani, Erica N Grodin, ReJoyce Green, Spencer Bujarski, Emily E Hartwell, Kelly E Courtney, Kent Hutchison, Karen Miotto, Lara A Ray

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Effect of alcohol, tobacco, and cannabis co-use on gray matter volume in heavy drinkers.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aaron C LimDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Dara G GhahremaniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Erica N GrodinDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
ReJoyce GreenDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Spencer BujarskiDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Emily E HartwellDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Kelly E CourtneyDepartment of Psychology, University of California, San Diego, San Diego, CA, USA.
Kent HutchisonDepartment of Psychology, University of Colorado, Boulder, CO, USA.
Karen MiottoDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: lararay@psych.ucla.edu.
University of California, Los Angeles · USUniversity of California San Diego · USUniversity of Colorado Boulder · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
UCLA Training Program in Translational Neuroscience of Drug Abuse (TNDA)T32DA024635 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY, Kate M Wassum · 2008 to 2026
$6.2M
UCLA DRUG ABUSE RESEARCH TRAINING PROGRAMT32DA007272 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRELLA, CHRISTINE E · 1991 to 2017
$4.9M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Optimizing Naltrexone for Individuals of East Asian DescentR01AA021744 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2013 to 2015
$1.3M
Elucidating the Effects of Neuroimmune Modulation on Neural Substrates of Alcohol Cue and Stress ReactivityF32AA027699 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GRODIN, ERICA N · 2019 to 2020
$103k
NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR033176NIAAA NIH HHS F32 AA027699NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R01 AA021744NIDA NIH HHS T32 DA007272NIDA NIH HHS T32 DA024635NIMH NIH HHS T32 MH018399
6 · The paper itself

Abstract

backgroundDespite known genetic variation across races, studies examining pharmacogenetics of a single nucleotide polymorphism (SNP) of the mu-opioid receptor gene (OPRM1) on clinical response to naltrexone have been conducted in predominantly Caucasian samples. Evidence is mixed for pharmacogenetic OPRM1 and naltrexone effects on neural responses to alcohol cues. The current study tests the pharmacogenetic effects of naltrexone and OPRM1 on neural responses to alcohol taste cues in heavy drinkers of East Asian descent.

methodsParticipants (N = 41) completed two double-blinded and counterbalanced functional magnetic resonance imaging (fMRI) sessions: one after taking naltrexone (50 mg/day) for four days and one after taking placebo for four days. Following titration, participants completed an fMRI alcohol taste-cues task. Analyses tested effects of naltrexone, OPRM1, and their interaction in whole-brain and region of interest (ROI) analyses of functional activation and functional connectivity in response to alcohol versus water taste cues.

resultsWe found no effects of naltrexone orOPRM1 on neural activation in whole-brain and ROI analyses, which included left and right ventral striatum (VS), anterior cingulate cortex (ACC), and orbitofrontal cortex (OFC). Naltrexone increased functional connectivity between left VS and clusters in medial prefrontal cortex, posterior cingulate gyrus, as well as right VS and occipital cortex, compared to placebo.

conclusionsNaltrexone treatment enhanced functional connectivity in a key reinforcement-related pathway during alcohol versus water taste cues, corroborating neuroimaging work with other substances. Null medication and pharmacogenetics effects on functional activation add to a mixed naltrexone literature and may underscore the modest size of these effects in East Asians.

Indexed as

Asian PeopleAdultAlcoholismAsia, EasternBrainDouble-Blind MethodFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNaltrexoneNarcotic AntagonistsNeuroimagingYoung AdultNaltrexoneNarcotic AntagonistsfMRINaltrexonePharmacogenetics

Identifiers

PMID31160146
PMCPMC6760244
OpenAlexW2944035695

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.