Evidence map›Paper›PMID 31159924›Full record

ArticleeLife2019

Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.

Matteo Fumagalli, Stephane M Camus, Yoan Diekmann, Alice Burke, Marine D Camus, Paul J Norman, Agnel Joseph, Laurent Abi-Rached, Andrea Benazzo, Rita Rasteiro and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. WEIRD bodies: mismatch, medicine and missing diversity.Evolution and human behavior : official journal of the Human Behavior and Evolution Society · 2020
    Article
  12. Article
  13. Membrane trafficking in health and disease.Disease models & mechanisms · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Matteo Fumagalli *Department of Life Sciences, Imperial College London, Ascot, United Kingdom.ORCID 0000-0002-4084-2953
Stephane M Camus *Research Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom.
Yoan Diekmann *Research Department of Genetics, Evolution and Environment, Division of Biosciences, University College London, London, United Kingdom.
Alice BurkeResearch Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom.
Marine D CamusResearch Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom.
Paul J NormanDivision of Bioinformatics and Personalized Medicine, University of Colorado, Aurora, United States.
Agnel JosephInstitute of Structural and Molecular Biology, Birkbeck College and University College London, London, United Kingdom.
Laurent Abi-RachedAix-Marseille Univ, IRD, MEPHI, IHU Méditerranée Infection, CNRS, Marseille, France.
Andrea BenazzoDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Rita RasteiroSchool of Biological Sciences, University of Bristol, Bristol, United Kingdom.ORCID 0000-0002-4217-3060
Iain MathiesonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Maya TopfInstitute of Structural and Molecular Biology, Birkbeck College and University College London, London, United Kingdom.
Peter ParhamDepartment of Structural Biology, Stanford University, Stanford, CA, United States.
Mark G ThomasResearch Department of Genetics, Evolution and Environment, Division of Biosciences, University College London, London, United Kingdom.
Frances M BrodskyResearch Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, United Kingdom.ORCID 0000-0002-1334-9258
Institute of Structural and Molecular Biology · GBStanford Medicine · USCentre National de la Recherche Scientifique · FRUniversity College London · GBUniversity of Bristol · GBUniversity of Colorado Anschutz Medical Campus · USUniversity of Ferrara · ITUniversity of Pennsylvania · US

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
Biochemistry and Cell Biology of CHC22 ClathrinR01DK095663 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRODSKY, FRANCES M. · 2013 to 2016
$1.4M
Medical Research Council MR/S008144/1NIAID NIH HHS U01 AI090905NIDDK NIH HHS R01 DK095663NIH HHS AI090905NIH HHS DK095663Wellcome TrustWellcome Trust 107858/Z/15/Z
6 · The paper itself

Abstract

CHC22 clathrin plays a key role in intracellular membrane traffic of the insulin-responsive glucose transporter GLUT4 in humans. We performed population genetic and phylogenetic analyses of the CHC22-encoding

Indexed as

Genetic VariationAllelesClathrin Heavy ChainsDietEvolution, MolecularGlucoseHumansSelection, GeneticClathrin Heavy ChainsCLTCL1 protein, humanGlucosecell biologyevolutionary biologyevolutionary selectionhumaninsulin responsemembrane traffic

Identifiers

PMID31159924
PMCPMC6548504
OpenAlexW2945821563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.