Evidence map›Paper›PMID 31159903›Full record

ArticleCardiology in the young2019

Potential risk factors for Ebstein anomaly, National Birth Defects Prevention Study, 1997-2011.

Karrie F Downing, Tiffany Riehle-Colarusso, Suzanne M Gilboa, Angela E Lin, Matthew E Oster, Sarah C Tinker, Sherry L Farr, National Birth Defects Prevention Study

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology in the young, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Case report of Ebstein's anomaly in a young female.SAGE open medical case reports · 2024
    Article
  4. Cannabis and Pregnancy: A Review.Obstetrical & gynecological survey · 2023
    Review
  5. A systematic review ofFrontiers in pediatrics · 2023
    Review
  6. [Ebstein's anomaly with ventricular preexcitation in an adult patient].Revista medica del Instituto Mexicano del Seguro Social · 2022
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Karrie F DowningDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.ORCID https://orcid.org/0000-0002-3063-1781
Tiffany Riehle-ColarussoDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.
Suzanne M GilboaDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.
Angela E LinMedical Genetics Unit, MassGeneral Hospital for Children,Boston, MA,USA.
Matthew E OsterDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.
Sarah C TinkerDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.
Sherry L FarrDivision of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention,Atlanta, GA,USA.
National Birth Defects Prevention Study
Centers for Disease Control and Prevention · USOak Ridge Associated Universities · USMassachusetts General Hospital · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundEbstein anomaly is a rare congenital heart defect (CHD) that, when severe, requires corrective surgery or other catheter-based intervention in the first year of life. Due to its rarity, risk factors for Ebstein anomaly remain largely unknown. Using national data, we examined 18 potential risk factors for Ebstein anomaly.

methodsUsing 1997-2011 data from the National Birth Defects Prevention Study, a population-based case-control study, we calculated crude and adjusted odds ratios and 95% confidence intervals for paternal age, maternal socio-demographics, reproductive history, and modifiable risk factors, and infant characteristics reported by mothers of 135 Ebstein anomaly cases and 11,829 controls.

resultsMothers of Ebstein anomaly cases had 4.1 (95% confidence interval: 1.8, 9.5) times the odds of reporting a family history of CHD compared with mothers of controls. Ebstein anomaly was associated with maternal second-hand cigarette smoke exposure at home (odds ratio = 2.2 [95% confidence interval: 1.1, 4.4]), but not maternal cigarette smoking (odds ratio = 1.3 [95% confidence interval: 0.8, 2.1]). Odds were elevated, but the 95% confidence interval included 1.0, for maternal marijuana use (odds ratio = 1.8 [95% confidence interval: 0.9, 3.8]) and paternal age ≥40 years at delivery (odds ratio = 1.9 [95% confidence interval: 1.0, 3.5]).

conclusionsMaternal exposure to second-hand cigarette smoke at home and a family history of CHD were associated with elevated odds of Ebstein anomaly. Genetic analyses could clarify the potential heritability of Ebstein anomaly.

Indexed as

RegistriesRisk AssessmentAdultEbstein AnomalyFemaleHumansIncidenceInfant, NewbornMaleMaternal ExposurePregnancyRetrospective StudiesRisk FactorsUnited StatesYoung Adultcase–control studycongenital heart defectEbstein anomalyprenatal exposurerisk factors

Identifiers

PMID31159903
PMCPMC6711372
OpenAlexW2948216516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.