Evidence map›Paper›PMID 31159890›Full record

ArticleActa neuropathologica communications2019

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease.

Vanessa Donega, Saskia M Burm, Miriam E van Strien, Emma J van Bodegraven, Iryna Paliukhovich, Hanneke Geut, Wilma D J van de Berg, Ka Wan Li, August B Smit, Onur Basak and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. Mitochondrial heterogeneity in diseases.Signal transduction and targeted therapy · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Vanessa DonegaDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Saskia M BurmDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Miriam E van StrienDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Emma J van BodegravenDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Iryna PaliukhovichDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.
Hanneke GeutDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Wilma D J van de BergDepartment of Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Ka Wan LiDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.
August B SmitDepartment of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands.
Onur BasakDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Elly M HolDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. E.M.Hol-2@umcutrecht.nl.ORCID 0000-0001-5604-2603
Amsterdam Neuroscience · NLUtrecht University · NLNetherlands Institute for Neuroscience · NLRoyal Netherlands Academy of Arts and Sciences · NL

Funding

Stichting Parkinson Fonds naZonMw 114021011ZonMw 116004204
6 · The paper itself

Abstract

It is currently accepted that the human brain has a limited neurogenic capacity and an impaired regenerative potential. We have previously shown the existence of CD271-expressing neural stem cells (NSCs) in the subventricular zone (SVZ) of Parkinson's disease (PD) patients, which proliferate and differentiate towards neurons and glial cells in vitro. To study the molecular profile of these NSCs in detail, we performed RNA sequencing and mass spectrometry on CD271

Indexed as

ProteomeTranscriptomeAgedAged, 80 and overFemaleHumansLateral VentriclesMaleNerve Tissue ProteinsNeural Stem CellsParkinson DiseaseReceptors, Nerve Growth FactorNerve Tissue ProteinsNGFR protein, humanProteomeReceptors, Nerve Growth FactorHuman SVZNeural stem cellsParkinson’s diseaseProteomicsQuiescenceRNA sequencingTranscriptomics

Identifiers

PMID31159890
PMCPMC6545684
OpenAlexW2947661900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.