Evidence map›Paper›PMID 31159832›Full record

ArticleJournal of experimental & clinical cancer research : CR2019

The m

Dongkui Gong, Jin Zhang, Yonghui Chen, Yunfei Xu, Junjie Ma, Guanghui Hu, Yiran Huang, Junhua Zheng, Wei Zhai, Wei Xue

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 113 citations in OpenAlex.

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  13. The regulatory role of m6A in cancer metastasis.Frontiers in cell and developmental biology · 2025
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  17. Review
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  19. Article
  20. Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Dongkui GongDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, 200072, China.
Jin ZhangDepartment of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200127, China.
Yonghui ChenDepartment of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200127, China.
Yunfei XuDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, 200072, China.
Junjie MaDepartment of Urology, Pudong Hospital, School of Medicine in Fudan University, Shanghai, 201300, China.
Guanghui HuDepartment of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, 200072, China.
Yiran HuangDepartment of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200127, China.
Junhua ZhengDepartment of Urology, Shanghai First People's Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200080, China. zhengjh0471@sina.com.cn.
Wei ZhaiDepartment of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200127, China. jacky_zw2002@hotmail.com.
Wei XueDepartment of Urology, Renji Hospital, School of Medicine in Shanghai Jiao Tong University, Shanghai, 200127, China. xuewei@renji.com.
Renji Hospital · CNShanghai Jiao Tong University · CNTongji University · CNFudan University · CNShanghai Tenth People's Hospital · CN

Funding

National Natural Science Foundation of China 31570775National Natural Science Foundation of China 81602216
6 · The paper itself

Abstract

backgroundPrevious study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of ATP and P2RX6, a preferred receptor for ATP, are still poorly studied in RCC.

methodsBioinformatics analysis was performed to identify the differentially expressed genes during RCC different stages. Tissue microarray, IHC staining and survival analysis was respectively used to evaluate potential clinical function. In vitro and in vivo assays were performed to explore the P2RX6 biological effects in RCC progression.

resultsWe found that ATP might increase RCC cells migration and invasion through P2RX6. Mechanism dissection revealed that ATP-P2RX6 might modulate the Ca

conclusionsOur findings revealed that the newly identified ATP-P2RX6-Ca

Indexed as

DNA MethylationAdenosine TriphosphateAnimalsCalciumCarcinoma, Renal CellCell Line, TumorCell MovementComputational BiologyDisease Models, AnimalGene Expression Regulation, NeoplasticHeterograftsHumansKidney NeoplasmsMatrix Metalloproteinase 9MiceMitogen-Activated Protein Kinase 1Adenosine TriphosphateCalciumMAPK1 protein, humanMatrix Metalloproteinase 9Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MMP9 protein, humanpurinoceptor P2X6Receptors, Purinergic P2Ca2+m6AP2RX6p-ERK1/2/MMP9Renal cell carcinoma

Identifiers

PMID31159832
PMCPMC6547495
OpenAlexW2948797227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.