Evidence map›Paper›PMID 31159807›Full record

ArticleRespiratory research2019

Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia.

Bodil Petersen, Cornelius J Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D Bloch, Donald B Bloch, Fumito Ichinose

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Bodil PetersenAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Cornelius J BuschAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. Cornelius.Busch@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6747-8805
Grigorij SchleiferAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Dominik SchaackDepartment of Anesthesiology, Ruprecht Karls University, Heidelberg, Germany.
Felix LasitschkaInstitute of Pathology, Ruprecht Karls University, Heidelberg, Germany.
Kenneth D BlochAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Donald B BlochAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Fumito IchinoseAnesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. FICHINOSE@mgh.harvard.edu.
Harvard University · USHeidelberg University · DE

Funding

Impact of nitric oxide synthase on myocardial dysfunction of sepsisR01GM079360 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI ICHINOSE, FUMITO · 2007 to 2011
$1.6M
Deutsche Forschungsgemeinschaft Open Access PublishingNational Institutes of Health GM79360NIGMS NIH HHS R01 GM079360
6 · The paper itself

Abstract

backgroundHypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for the effect of endotoxin on HPV. The aim of the current study was to identify additional factors that might contribute to the impairment of HPV during endotoxemia.

methodsGene expression profiling was determined using pulmonary tissues from NOS2-deficient (NOS2

resultsAmong the 22,690 genes analyzed, endotoxin induced a greater than three-fold increase in 59 and 154 genes in the lungs of wild-type and NOS2

conclusionsThe results of this study suggest that endotoxemia induces Arg1 and that arginase contributes to the endotoxin-induced impairment of HPV in mice.

Indexed as

AnimalsArginaseEndotoxemiaMaleMiceMice, Inbred C57BLMice, KnockoutPulmonary CirculationVascular ResistanceVasoconstrictionArginaseArginaseEndotoxemiaHypoxic pulmonary vasoconstrictionNitric oxide synthase

Identifiers

PMID31159807
PMCPMC6547543
OpenAlexW2948886344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.